Inhibition of ultraviolet-B-induced wrinkle formation by an elastase-inhibiting herbal extract: implication for the mechanism underlying elastase-associated wrinkles

International Journal of Dermatology
K TsukaharaGenji Imokawa

Abstract

Previously, we have demonstrated that fibroblast-derived elastase plays an essential role in the increased three-dimensional tortuosity of elastic fibers, contributing to the loss of skin elasticity in UV-B-exposed skin. This decrease in skin elasticity is closely associated with the formation of wrinkles induced by UV exposure. To further clarify the role of elastase in the formation of wrinkles induced by UV exposure, we assessed the effects of an extract of Zingiber officinale (L.) Rose (which inhibits fibroblast-derived elastase) on the wrinkle formation induced by chronic UV-B irradiation. Topical application of an extract of Zingiber officinale (L.) Rose to rat or hairless mouse skin significantly inhibited the wrinkle formation induced by chronic UV-B irradiation at a suberythemal dose, which was accompanied by a significant prevention of the decrease in skin elasticity in both types of animal skin. In the rat hind limb skin, consistent with the inhibition of reduced skin elasticity, wrinkle prevention occurred concomitantly with a significant decrease in the curling and three-dimensional tortuosity of dermal elastic fibers. Our results indicate that herbal extracts with an ability to inhibit fibroblast-derived elastase ...Continue Reading

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Citations

Mar 17, 2009·Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine·Ling Zhang, Wen-jun Wang
Apr 23, 2011·Bioscience, Biotechnology, and Biochemistry·Itaru UrikuraTakashi Hirata
Sep 22, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Pham Thi Be Tu, Shinkichi Tawata
Feb 6, 2014·Expert Opinion on Drug Discovery·Azadeh ManayiMohammad Abdollahi
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Oct 5, 2010·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Jeong Mok ChoSang Woo Lee
Oct 3, 2008·Journal of Dermatological Science·Won-Serk KimJong-Hyuk Sung
Mar 22, 2016·Journal of Dermatological Science·Chi-Yung ChenJehng-Kang Wang
Oct 27, 2009·Phytotherapy Research : PTR·Melainie CameronSigrun Chrubasik
Nov 7, 2012·Photodermatology, Photoimmunology & Photomedicine·Saho SugimotoFumiyasu Ishikawa
Jan 1, 2014·Korean Journal for Food Science of Animal Resources·Jinhee YooYoungjae Shin
Mar 16, 2012·The Biochemical Journal·Hiroaki NakajimaGenji Imokawa
Nov 9, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Hsiu-Mei ChiangKuo-Ching Wen
Dec 9, 2014·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Jae Hoon JeongSukwha Kim
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Dec 2, 2010·The Journal of Craniofacial Surgery·Minoru Ueda, Yudai Nishino
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Jul 21, 2020·Oxidative Medicine and Cellular Longevity·Hee-Jeong ChoiSang-Han Lee
Jan 29, 2021·Journal of Food Science and Technology·Boo-Sik JangNoh-Hee Jeong

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