Inhibition of urea synthesis by pent-4-enoic acid: potentiation by ammonia

Biochemical and Biophysical Research Communications
F X Coude, G Grimber


Pent-4-enoic acid inhibited ureagenesis approximatively 90% in rat hepatocytes incubated with pyruvate, ammonia and ornithine. Inhibition of ureagenesis was much less with alanine as substrate (approximatively 10%). The addition of ammonia led to a drastic dose-dependent inhibition of ureagenesis by pent-4-enoate. Half-maximum effect of ammonia was observed at 0.2 mM concentration. Concomitant cellular concentrations of N-acetylglutamate were also drastically modified by the addition of ammonia as was the accumulation of citrulline. These data suggest that ammonia may seriously interfere with the metabolism of pent-4-enoic acid and leads to a dramatic potentiation of its toxicity.


Nov 1, 1977·Archives of Biochemistry and Biophysics·M E TischlerJ R Williamson
Mar 1, 1978·European Journal of Biochemistry·K Shigesada, M Tatibana
Mar 1, 1975·Pediatric Research·A M Glasgow, H P Chase
Sep 1, 1969·British Medical Bulletin·H S Sherratt
Dec 1, 1967·Proceedings of the National Academy of Sciences of the United States of America·C CorredorR Bressler
Jun 1, 1965·Clinica Chimica Acta; International Journal of Clinical Chemistry·G Ceriotti, L Spandrio
Apr 29, 1980·Biochemical and Biophysical Research Communications·B BorrebaekJ Bremer

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