PMID: 6166003Apr 1, 1981Paper

Inhibition of vaccinia mRNA methylation by 2',5'-linked oligo(adenylic acid) triphosphate

Proceedings of the National Academy of Sciences of the United States of America
O K Sharma, B B Goswami

Abstract

Extracts of interferon-treated cells synthesize unique 2',5'-linked oligo(adenylic acid) 5'-phosphates in the presence of ATP and double-stranded RNA. 2',5'-linked oligo(adenylic acid) 5'-triphosphate inhibits protein synthesis at nanomolar concentrations by activating RNase. We have observed that oligo(adenylic acid) 5'-monophosphate and 5'-triphosphate are potent inhibitors of vaccinia mRNA methylation in vitro. Both the methylation of mRNA methylation is not due to degradation of the mRNA. Inhibition of the 5'-terminal guanine at the 7 position and the 2'-O-ribose methylation of the penultimate nucleoside are inhibited. Such inhibition of the requisite modification of the 5' terminus of mRNA by 2',5'-linked oligo(adenylic acids) may be a mechanism of interferon action against both DNA and RNA viruses in which mRNAs derived from them are capped.

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Citations

Jan 1, 1984·Pharmacology & Therapeutics·G C Sen
Jun 1, 1991·Journal of Interferon Research·F J CastoraP F Torrence
Jul 31, 2012·Antiviral Research·François FerronBruno Canard
May 29, 1987·Biochemical and Biophysical Research Communications·D K Liu, G F Owens
Nov 16, 1993·Biochemistry·R W SobolR J Suhadolnik
Jul 25, 1983·FEBS Letters·O K SharmaB B Goswami

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