Abstract
Vascular endothelial growth factor (VEGF)-A is an important mediator of angiogenesis in almost all solid tumors. The aim of this study was to evaluate the effect of VEGF-A expression on tumor growth, perfusion, and chemotherapeutic efficacy in orthotopic 9L gliosarcomas. Stable 9L cell lines underexpressing and overexpressing VEGF-A were generated. Anatomic, susceptibility contrast, and continuous arterial spin-labeling magnetic resonance imaging were used to quantify the volume, blood volume, and blood flow of tumors orthotopically grown from these and wild-type 9L cells. Histologic, immunohistochemical, and quantitative reverse transcription-PCR analyses were also done on excised tumors. Finally, the effects of carmustine chemotherapy were also evaluated. Orthotopic tumors underexpressing VEGF-A had slower growth rates (increased median survival), greater blood flow, vessel density, and VEGF-D expression, but no statistical difference in blood volume and chemotherapeutic sensitivity, compared with tumors with wild-type levels of VEGF-A. Tumors overexpressing VEGF-A had faster growth rates, greater blood volume, vessel density, and blood flow but no statistical difference in VEGF-D expression and chemotherapeutic sensitivity c...Continue Reading
References
Apr 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·G ConnK A Thomas
Jul 4, 1990·Journal of the National Cancer Institute·P SkehanM R Boyd
Nov 18, 1971·The New England Journal of Medicine·J Folkman
Oct 1, 1995·Nature Medicine·T AlonE Keshet
Aug 6, 1996·Proceedings of the National Academy of Sciences of the United States of America·S Y ChengW K Cavenee
Oct 15, 1996·Proceedings of the National Academy of Sciences of the United States of America·M OrlandiniS Oliviero
Apr 17, 1997·Nature·W Risau
Jan 22, 1998·Proceedings of the National Academy of Sciences of the United States of America·M G AchenS A Stacker
Aug 18, 1999·Proceedings of the National Academy of Sciences of the United States of America·L MarconciniS Oliviero
Nov 5, 1999·The Journal of Biological Chemistry·S A StackerM G Achen
Nov 26, 1999·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·M SasakiK H Plate
Aug 6, 2000·European Journal of Radiology·R Brasch, K Turetschek
Jan 9, 2001·Seminars in Radiation Oncology·M NeemanM W Dewhirst
Feb 15, 2001·Nature Medicine·S A StackerM G Achen
Mar 10, 2001·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·I TroprèsM Décorps
Mar 10, 2001·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·H KobayashiM W Brechbiel
Dec 12, 2001·The British Journal of Surgery·M L GeorgeR I Swift
Jun 5, 2003·Nature Medicine·Rakesh K Jain
Jan 28, 2004·Neurosurgery·Giselle Fabiana PrunellNiels-Aage Svendgaard
Jan 28, 2004·Nature Medicine·Christopher G WillettRakesh K Jain
Jun 24, 2004·Brain Research. Brain Research Reviews·Marnix JansenCornelis J F van Noorden
Sep 1, 2004·Neurosurgery·Einat PelesZvi Ram
Nov 24, 2004·Journal of Magnetic Resonance Imaging : JMRI·N Shastry AkellaL Burt Nabors
Dec 8, 2004·Magma·B A MoffatB D Ross
Dec 21, 2004·Cancer Cell·Frank WinklerRakesh K Jain
Jan 8, 2005·Science·Rakesh K Jain
Jan 25, 2005·Proceedings of the National Academy of Sciences of the United States of America·Martin HagedornAndreas Bikfalvi
Feb 3, 2005·Journal of the National Cancer Institute·Janet C MillerJames H Thrall
Feb 8, 2005·Radiologic Clinics of North America·Joseph G Rajendran, Kenneth A Krohn
Feb 15, 2005·The Oncologist·Shazza Rehman, Gordon C Jayson
Feb 22, 2005·Journal of Magnetic Resonance Imaging : JMRI·Bradford A MoffatBrian D Ross
Citations
Apr 17, 2008·Cancer Metastasis Reviews·Aaron P BrownKevin A Camphausen
Aug 8, 2008·Expert Reviews in Molecular Medicine·Joshua C AndersonCandece L Gladson
Feb 19, 2010·Human Gene Therapy·Haritha SamaranayakeSeppo Ylä-Herttuala
Oct 7, 2008·The Cancer Journal·John F de Groot, Wai Kwan Alfred Yung
Dec 14, 2012·Journal of Biomedical Optics·Abhishek RegeNitish V Thakor
Feb 10, 2011·PloS One·Moses M DarpolorKathleen M Schmainda
Oct 23, 2013·Annals of Surgical Oncology·Elena SanmartínCarlos Camps
Dec 24, 2011·AJNR. American Journal of Neuroradiology·A R BorgesS G Cerdan
Feb 14, 2013·The Journal of Biological Chemistry·Nicole C HarrisMarc G Achen
Dec 12, 2007·British Journal of Neurosurgery·M D JenkinsonT S Smith
Dec 5, 2009·Neuroimaging Clinics of North America·Bradford A MoffatAlnawaz Rehemtulla
May 14, 2008·Magnetic Resonance Imaging Clinics of North America·Shin MatsuokaHiroto Hatabu
Nov 30, 2007·Free Radical Biology & Medicine·Sabrina DoblasRheal A Towner
Jul 12, 2007·Journal of Magnetic Resonance Imaging : JMRI·Tristan BarrettPeter L Choyke
Jul 19, 2012·Histopathology·Pramila RamaniChris Rogers
Jan 22, 2013·NMR in Biomedicine·Olivier ReynaudLuisa Ciobanu
Jan 10, 2014·Cancer Medicine·Reshmi RajendranKai Hsiang Chuang
May 15, 2015·Journal of Experimental & Clinical Cancer Research : CR·Caren JayasingheCharles James Kirkpatrick
Jun 25, 2015·NMR in Biomedicine·Reshmi RajendranKai-Hsiang Chuang
Apr 23, 2015·Critical Reviews in Oncology/hematology·Artrish JeffersonAbigail Hielscher
Dec 14, 2016·Journal of Cellular and Molecular Medicine·Izabela Papiewska-PająkJoanna Boncela
Nov 6, 2018·Molecular Diagnosis & Therapy·Tanvi VaidyaAbhishek Mahajan
Apr 3, 2019·International Journal of Molecular Sciences·Sukriti NagDuncan J Stewart
May 2, 2007·The Oncologist·Suresh Senan, Egbert F Smit
Jul 12, 2017·Oncology Letters·Yan-Juan ZhuXian Chen
Feb 11, 2011·Journal of Neuro-oncology·S GrauC Schichor
Nov 23, 2006·Journal of Neuro-oncology·S J GrauR Goldbrunner