Inhibition of vasoconstrictor responses by 6-keto-PGE1 in the feline mesenteric vascular bed

Prostaglandins
H L LipptonP J Kadowitz

Abstract

The effects of 6-keto-PGE1 on vascular resistance and vascular responses to sympathetic nerve stimulation and vasoconstrictor hormones were investigated in the feline mesenteric vascular bed. Infusions of 6-keto-PGE1 into the superior mesenteric artery dilated the mesenteric vascular bed and markedly inhibited vasoconstrictor responses to sympathetic nerve stimulation, norepinephrine and angiotensin II. The effects of 6-keto-PGE1 and PGE1 on vascular resistance and vasoconstrictor responses were quite similar and both substances inhibited responses to nerve stimulation and pressor hormones in a reversible manner. Responses to nerve stimulation, norepinephrine and angiotensin II were inhibited to a similar extent during infusion of 6-keto-PGE1 and PGE1. Results of these studies suggest that 6-keto-PGE1, a newly identified prostaglandin metabolite, and PGE1 possess the ability to inhibit the vasoconstrictor effects of sympathetic nerve stimulation and pressor hormones by a non-specific action on vascular smooth muscle in the feline small intestine.

References

Dec 1, 1976·Prostaglandins·N WhittakerF F Sun
Sep 1, 1979·Circulation Research·A L Hyman, P J Kadowitz
Jul 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·A L HymanJ Barton
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Citations

Oct 1, 1983·Prostaglandins·P K Moore, R J Griffiths
Jan 1, 1982·Prostaglandins, Leukotrienes, and Medicine·D G Chang, H H Tai
Dec 1, 1984·Prostaglandins, Leukotrienes, and Medicine·R LewisG Beck
Apr 1, 1987·Prostaglandins, Leukotrienes, and Medicine·H L LipptonP J Kadowitz
Dec 1, 1988·Clinical and Experimental Pharmacology & Physiology·M P RechtmanA L Boura
May 1, 1981·Prostaglandins and Medicine·E G PontecorvoP J Kadowitz
May 1, 1983·British Journal of Pharmacology·R J Griffiths, P K Moore
Nov 1, 1983·The Journal of Pharmacy and Pharmacology·U Förstermann, B Neufang
Dec 1, 1990·Prostaglandins, Leukotrienes, and Essential Fatty Acids·D M CliveE W Salzman

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