PMID: 8971048Dec 1, 1996Paper

Inhibition of viral replication reverses respiratory syncytial virus-induced NF-kappaB activation and interleukin-8 gene expression in A549 cells

Journal of Virology
M A FiedlerJ M Stark

Abstract

Previous studies have demonstrated that respiratory syncytial virus (RSV) infection of airway epithelial cells results in the expression of a number of cytokines, such as interleukin-8 (IL-8), that are transcriptionally regulated by nuclear factor kappaB (NF-kappaB). In the studies reported here, we demonstrate that treatment of RSV-infected A549 cells with 100 microg of ribavirin (a viral replication inhibitor) per ml results in reversal of RSV-induced NF-kappaB activation, IL-8 mRNA expression, and IL-8 protein production in A549 cells. These data confirm that viral replication is a key step in RSV-induced NF-kappaB activation and IL-8 production.

References

Feb 1, 1987·Molecular and Cellular Biology·J R de WetS Subramani
Nov 1, 1985·Archives of Disease in Childhood·M S WebbA S Swarbrick
Sep 1, 1984·The Journal of Pediatrics·C B HallJ P Leddy
Sep 14, 1984·Biochimica Et Biophysica Acta·W R RiceJ A Whitsett
Mar 1, 1995·The Journal of Infectious Diseases·T L NoahS Becker
Jan 1, 1994·Annual Review of Immunology·P A Baeuerle, T Henkel
Nov 1, 1993·The American Journal of Physiology·T L Noah, S Becker
Dec 1, 1995·The American Journal of Physiology·M A FiedlerJ M Stark
Jul 1, 1996·The American Journal of Physiology·B B WarnerJ R Wispé

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Citations

Nov 20, 1998·Allergy·S L Johnston
Sep 10, 2003·Proceedings of the National Academy of Sciences of the United States of America·Santanu BoseAmiya K Banerjee
Jul 27, 2004·American Journal of Physiology. Lung Cellular and Molecular Physiology·Thierry RogerRené Lutter
Jul 22, 1998·Scandinavian Journal of Infectious Diseases·W De WeerdJ L Kimpen
Aug 19, 2005·Nature·Jordan J Feld, Jay H Hoofnagle
Feb 13, 2004·FEBS Letters·Xiaoyuan KongShyam S Mohapatra
Dec 31, 2010·Endocrinology·Adam HinzeyJeanette I Webster Marketon
May 23, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·A CasolaA R Brasier
Apr 16, 2004·Clinical Microbiology Reviews·Andrew J EastonHelene F Rosenberg
Feb 13, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·M MonickG Hunninghake
Jun 21, 2008·Journal of Gastroenterology and Hepatology·Paul Martin, Donald M Jensen
Feb 26, 2005·Journal of Virology·Brian D RuddNicholas W Lukacs
Mar 30, 2012·Expert Review of Respiratory Medicine·Farnoosh Tayyari, Richard G Hegele
Sep 19, 2003·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Santanu Bose, Amiya K Banerjee
Aug 12, 1998·American Journal of Respiratory Cell and Molecular Biology·M A FiedlerJ M Stark
Jul 16, 2010·Leukemia & Lymphoma·Katherine L B Borden, Biljana Culjkovic-Kraljacic
Sep 15, 2011·Immunotherapy·Aarthi Chary, Mark Holodniy
Jan 3, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·D HamamdzicL London
Apr 29, 1999·Clinical Immunology : the Official Journal of the Clinical Immunology Society·D HamamdzicL London
Jun 14, 2003·Biochemical and Biophysical Research Communications·Xiaoyuan KongShyam S Mohapatra

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