PMID: 9184803May 1, 1997Paper

Inhibition of voltage-dependent Ca2+ channels of porcine tracheal smooth muscle by the novel Ca2+ channel antagonist RWJ-22108

General Pharmacology
Michiaki YamakageT L Croxton

Abstract

1. We compared electrophysiological effects of the bronchoselective Ca2+ channel antagonist RWJ-22108 on voltage-dependent Ca2+ channels (VDCs) of porcine tracheal smooth muscle cells to the effects of nicardipine and verapamil. 2. Each of the three Ca2+ channel antagonists tested inhibited inward Ca2+ currents (ICa) measured by whole-cell patch clamp techniques. Inhibition was dose-dependent with approximately 50% inhibition of peak ICa at +20 mV obtained with 3 x 10(-6) M RWJ-22108, 3 x 10(-7) M nicardipine, or 10(-5) M verapamil. 3. Both RWJ-22108 (3 x 10(-6) M) and nicardipine (3 x 10(-7) M) shifted the voltage dependence of steady-state inactivation to more negative potentials; however, the change in the potential of half-maximal inactivation induced by RWJ-22108 (-18 mV) was significantly greater than that induced by nicardipine (-12 mV). Verapamil did not alter the voltage dependence of inactivation. 4. We conclude that inhibition of VDCs by RWJ-22108 is qualitatively similar to that by nicardipine but with a greater stabilizing effect on the inactivated channel state.

References

Jan 1, 1976·The Japanese Journal of Physiology·H SuzukiH Kuriyama
Sep 1, 1991·The American Journal of Physiology·J P BourreauE E Daniel
Jun 1, 1990·Pflügers Archiv : European journal of physiology·H OzakiH Karaki
May 1, 1987·Pflügers Archiv : European journal of physiology·K TeradaH Kuriyama
Jun 1, 1988·The American Journal of Physiology·M I Kotlikoff
Jul 18, 1989·European Journal of Pharmacology·G Haeusler, J E De Peyer
Sep 1, 1989·The American Journal of Physiology·P D LangtonK M Sanders
Oct 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·B P Bean
Aug 1, 1981·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·M SouhradaR M Cherniack
Aug 1, 1981·Pflügers Archiv : European journal of physiology·O P HamillF J Sigworth
Oct 1, 1982·Pflügers Archiv : European journal of physiology·G Isenberg, U Klockner
Aug 1, 1994·Cardiovascular Drugs and Therapy·R FerrariO Visioli
Sep 1, 1993·Agents and Actions·J B MooreS Mockoviak
Jan 1, 1994·Annual Review of Neuroscience·F HofmannV Flockerzi
Jan 1, 1993·International Archives of Allergy and Immunology·D M RitchieR J Capetola

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Citations

Feb 2, 2002·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Michiaki Yamakage, Akiyoshi Namiki
Jun 5, 1999·Anesthesia and Analgesia·M YamakageA Namiki
Jul 1, 2006·World Journal of Gastroenterology : WJG·Qing CaiXiao-Li Fan

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