Inhibition of voltage-dependent sodium channels suppresses the functional magnetic resonance imaging response to forepaw somatosensory activation in the rodent

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
Ikuhiro KidaK L Behar

Abstract

Results of recent studies suggest that the glutamate-glutamine neurotransmitter cycle between neurons and astrocytes plays a major role in the generation of the functional imaging signal. In the current study, the authors tested the hypothesis that activation of voltage-dependent Na(+) channels is involved in the blood oxygenation level-dependent (BOLD) functional magnetic resonance imaging (fMRI) responses during somatosensory activation. The BOLD fMRI and cerebral blood flow (CBF) experiments were performed at 7 Tesla on alpha-chloralose-anesthetized rats undergoing forepaw stimulation before and for successive times after application of lamotrigine, a neuronal voltage-dependent Na+ channel blocker and glutamate release inhibitor. The BOLD fMRI signal changes in response to forepaw stimulation decreased in a time-dependent manner from 6.7% +/- 0.7% before lamotrigine injection to 3.0% +/- 2.5% between 60 and 105 minutes after lamotrigine treatment. After lamotrigine treatment, the fractional increase in CBF during forepaw stimulation was an order of magnitude less than that observed before the treatment. Lamotrigine had no effect on baseline CBF in the somatosensory cortex in the absence of stimulation. These results strongly...Continue Reading

References

Jul 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·S OgawaK Ugurbil
Aug 1, 1988·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M UekiK A Hossmann
Oct 20, 1984·The Journal of Comparative Neurology·J K Chapin, C S Lin
Feb 1, 1995·Journal of Neurochemistry·I LizasoainS Moncada
Jan 1, 1995·Stroke; a Journal of Cerebral Circulation·S E Smith, B S Meldrum
Oct 25, 1994·Proceedings of the National Academy of Sciences of the United States of America·L Pellerin, P J Magistretti
Jul 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·F HyderR G Shulman
Jul 23, 1996·Proceedings of the National Academy of Sciences of the United States of America·F HyderR G Shulman
May 1, 1997·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·J von WegererJ Walden
Jul 1, 1997·British Journal of Pharmacology·C C Kuo, L Lu
Nov 5, 1997·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·F HyderR G Shulman
Feb 21, 1998·Proceedings of the National Academy of Sciences of the United States of America·N R SibsonR G Shulman
Aug 4, 1998·Journal of Applied Physiology·F HyderD L Rothman
Oct 20, 1998·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S D FormanA P Koretsky
Nov 11, 1998·European Journal of Pharmacology·E SouthamR M Hagan
Apr 16, 1999·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·G BrinkerM Hoehn-Berlage
Aug 24, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·A C SilvaS G Kim
Aug 31, 1999·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·D L RothmanR G Shulman
Mar 21, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·F HyderD Rothman
May 29, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·I KidaF Hyder
Sep 27, 2000·Proceedings of the National Academy of Sciences of the United States of America·S OgawaK Ugurbil

❮ Previous
Next ❯

Citations

Jul 23, 2002·Proceedings of the National Academy of Sciences of the United States of America·Arien J SmithFahmeed Hyder
Jan 14, 2003·Annual Review of Physiology·Douglas L RothmanRobert G Shulman
Mar 12, 2013·Neural Plasticity·Mara Fabri, Gabriele Polonara
Dec 31, 2004·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Ikuhiro KidaFahmeed Hyder
Nov 15, 2007·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Kirsten CaesarMartin Lauritzen
Oct 27, 2004·NeuroImage·Richard B BuxtonThomas T Liu
May 1, 2012·NeuroImage·Fahmeed Hyder, Douglas L Rothman
Jan 20, 2007·NeuroImage·Roberto C Sotero, Nelson J Trujillo-Barreto
Nov 18, 2010·Brain Research·Mara FabriTullio Manzoni
Oct 26, 2012·L'Encéphale·M DupuyC Bungener
Oct 13, 2006·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Ikuhiro KidaFahmeed Hyder
Jun 17, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Hubert K F TrübelFahmeed Hyder
Apr 22, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Xingbao LiMark S George
Jan 1, 2015·World Journal of Radiology·Mara FabriGabriele Polonara
Sep 5, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Ikuhiro KidaFahmeed Hyder
Dec 22, 2004·Nature Reviews. Neuroscience·Martin Lauritzen
Jan 8, 2011·Journal of Integrative Neuroscience·M J RosaK J Friston
Jan 22, 2021·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Yury KoushFahmeed Hyder

❮ Previous
Next ❯

Methods Mentioned

BETA
NMR

Software Mentioned

MATLAB

Related Concepts

Related Feeds

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.