PMID: 816773Apr 1, 1976

Inhibition of wall autolysis in Streptococcus faecalis by lipoteichoic acid and lipids

Journal of Bacteriology
R F ClevelandG D Shockman

Abstract

Fully acylated lipoteichoic acid (LTA) isolated from Streptococcus faecalis ATCC9790 (S. faecium) inhibited autolysis of walls from the same organism at concentrations (1.0 to 1.5 nmol of LTA per mg of wall) comparable to those found in intact cells. Partially deacylated LTA isolated from S. faecalis or chemically deacylated LTA failed to inhibit significantly in the same concentration range. Beef heart cardiolipin and commercially obtained dipalmitoyl phosphatidyl glycerol were also found to inhibit wall autolysis in S. faecalis. Chemical deacylation of beef heart cardiolipin also removed the inhibitory activity of this molecule. Lipid fractions isolated from S. faecalis that inhibited wall autolysis were: diphosphatidyl glycerol (cardiolipin), phosphatidyl glycerol, aminoacyl phosphatidyl glycerol, and a neutral lipid fraction. Glycolipids were not found to be effective inhibitors. The possible role of LTA and/or certain lipids as regulators of cellular autolytic activity is discussed.

Citations

Jan 15, 1985·European Journal of Biochemistry·T Briese, R Hakenbeck
Jul 1, 1983·European Journal of Biochemistry·W FischerR Haas
Jan 1, 1987·Critical Reviews in Microbiology·R J Doyle, A L Koch
Sep 1, 1992·Molecular Microbiology·M L Higgins, P J Piggot
Apr 1, 1996·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·P Canepari, M Boaretti
May 2, 2000·Applied and Environmental Microbiology·C SignorettoP Canepari
Mar 1, 1980·Journal of Periodontal Research·R L O'GradyA J Wicken
Feb 13, 2008·FEMS Microbiology Reviews·Waldemar VollmerSimon Foster
Feb 3, 2016·Journal of Bacteriology·Christopher M Johnson, Alan D Grossman
Sep 1, 1990·The Journal of Applied Bacteriology·A GálvezM Maqueda
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Mar 13, 1999·The Journal of Clinical Investigation·A K Foreman-WykertJ Weiss

Related Concepts

Acylation
Bacteriolysis
Diphosphatidylglycerols
Bos indicus
Cell Wall
Heart
Lipids
Monophosphatidylglycerols
Enterococcus faecalis
Teichoic Acids

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