Inhibition on cholinesterase and tyrosinase by alkaloids and phenolics from Aristotelia chilensis leaves

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Carlos L CespedesIsao Kubo

Abstract

It is reported in this study the effect of isolates from leaves of Aristotelia chilensis as inhibitors of acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and tyrosinase enzymes. The aim of the paper was to evaluate the activity of A. chilensis towards different enzymes. In addition to pure compounds, extracts rich in alkaloids and phenolics were tested. The most active F5 inhibited AChE (79.5% and 89.8% at 10.0 and 20.0 μg/mL) and against BChE (89.5% and 97.8% at 10.0 and 20.0 μg/mL), showing a strong mixed-type inhibition against AChE and BChE. F3 (a mixture of flavonoids and phenolics acids), showed IC50of 90.7 and 59.6 μg/mL of inhibitory activity against AChE and BChE, inhibiting the acetylcholinesterase competitively. Additionally, F3 showed and high potency as tyrosinase inhibitor with IC50at 8.4 μg/mL. Sample F4 (anthocyanidins and phenolic composition) presented a complex, mixed-type inhibition of tyrosinase with a IC50of 39.8 μg/mL. The findings in this investigation show that this natural resource has a strong potential for future research in the search of new phytotherapeutic treatments for cholinergic deterioration ailments avoiding the side effects of synthetic drugs. This is the first report as cholinest...Continue Reading

Citations

Mar 30, 2017·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Jianbo Xiao, Milen I Georgiev
Feb 22, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dora MelucciMohamad Fawzi Mahomoodally
Jul 31, 2018·Journal of Biomolecular Structure & Dynamics·Sengul UysalFawzi M Mahomoodally
Nov 25, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Fredi CifuentesCristian Paz
Aug 1, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Fernando RomeroFredi Cifuentes
Jul 29, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tanja M LunićBiljana Dj Božić Nedeljković
Dec 22, 2019·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·José Miguel Bastías-MontesCarlos L Cespedes-Acuña
Jul 12, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·A M SwarazMd Obayed Raihan
Jan 7, 2022·The Journal of Organic Chemistry·Alexander V AksenovMichael Rubin

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