PMID: 137766Jan 14, 1977

Inhibiton of neurons in the amygdala by dorsal raphe stimulation: mediation through a direct serotonergic pathway

Brain Research
R Y Wang, G K Aghajanian


This study presents data showing that the dorsal raphe nucleus (DRN) has a marked inhibitory influence upon neurons in the amygdala and that this inhibitory effect is mediated by a direct DRN-amygdala serotonergic pathway. The evidence may be briefly summarized as follows:(1) on the same amygdaloid cells, both iontophoresis of serotonin (5-HT) and electrical stimulation of the DRN markedly inhibited spontaneous single unit activities; (2) the latency of DRN-induced inhibition was relatively short and is compatible with the conduction velocities (which were determined by antidromic activation of the 5-HT pathway) of unmyelinated 5-HT fibers; (3) destruction of 5-HT projections by 5,7-dihydroxytryptamine (5,7-DHT) or pharmacological depletion of 5-HT by parachlorophenylalanine (PCPA) prevented the inhibitory responsed to DRN stimulation in the great majority of cells studied; (4) in PCPA-pretreated animals, injection of 5-hydroxytryptophan (5-HTP) reversed the PCPA effect, restoring the responses of amygdaloid cells to DRN stimulation. In the amygdala, the presumptive 5-HT antagonists which we tested did not block the inhibitory effects of 5-HT except that intravenously administered LSD blocked the inhibitory responses produced b...Continue Reading


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Apr 1, 1992·Biulleten' eksperimental'noĭ biologii i meditsiny·G F Molodtsova
Sep 1, 1977·Electroencephalography and Clinical Neurophysiology·R Y Wang, G K Aghajanian
Sep 15, 1978·European Journal of Pharmacology·J Davies, P Tongroach
Oct 15, 1978·European Journal of Pharmacology·H J Haigler
Jul 25, 1980·European Journal of Pharmacology·R B McCall, G K Aghajanian
Dec 17, 1981·European Journal of Pharmacology·M A BlackshearE Sanders-Bush
Mar 18, 1983·European Journal of Pharmacology·T AkasuK Koketsu
Feb 1, 1987·Journal of the Neurological Sciences·G EbingerL Gommé
Aug 1, 1980·Physiology & Behavior·W KostowskiA Płaźnik
Jan 1, 1996·Behavioural Brain Research·K A CunninghamM E Reith
Jan 1, 1980·Progress in Neurobiology·A Dray
Jan 1, 1979·Progress in Neuro-psychopharmacology·S P AllegraP Mandel
Jan 1, 1985·Behavioral and Neural Biology·O PuciłowskiW Kostowski
Jan 22, 2013·ACS Chemical Neuroscience·Stefanie C AltieriAnne M Andrews


Feb 13, 1976·Brain Research·M Segal
Oct 24, 1975·Brain Research·M BrownsteinJ S Kizer
Apr 10, 1965·Nature·R C Thomas, V J Wilson
Oct 25, 1974·Brain Research·J M SaavedraM Palkovits
Jan 1, 1971·Naunyn-Schmiedebergs Archiv Für Pharmakologie·P BédardM Lindqvist
Jul 1, 1974·The Journal of Comparative Neurology·L C ConradD W Pfaff
Dec 21, 1973·Zeitschrift für Zellforschung und mikroskopische Anatomie·A BjörklundU Stenevi
Apr 12, 1974·Brain Research·D A Kovacs, J G Zoll
Apr 21, 1967·Science·G K AghajanianM H Sheard
Jun 30, 1972·Science·J H LaVail, M M LaVail
Aug 1, 1969·European Journal of Pharmacology·W KostowskiL Valzelli
Nov 1, 1968·European Journal of Pharmacology·W KostowskiL Valzelli
Apr 1, 1969·Brain Research·G K AghajanianM H Sheard
Aug 1, 1964·Psychological Bulletin·G V GODDARD

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