Inhibitor-associated transposition events in Corynebacterium glutamicum

Molecular Genetics and Genomics : MGG
T R GarbeH Yukawa

Abstract

In up to 100% of all bacteria grown in the presence of initially inhibitory concentrations of five diverse inhibitors, an extra copy of the resident insertion element IS 31831 was found in specific chromosomal regions, the sites of which apparently depended on the inhibitor used. Thus, in nine out of nine independently isolated cyanide-associated transpositions, the acquired copy was located within an ORF encoding a protein related to the hypothetical but conserved protein YeiH of Escherichia coli. A putative Sox box upstream of the yeiH gene implicates superoxide as a potential regulator of the gene, a possibility further supported by the finding that superoxide dismutase (SodA) is overexpressed in cells cultured in cyanide-containing medium. Neither the cyanide-associated nor any of the other transposition mutations appeared to confer any discernible phenotypic advantage upon cells grown in the presence or absence of the inhibitors, as revealed most stringently by mixed-cell experiments. An alternative, albeit heterodox, explanation for the emergence of the mutants postulates a very high rate of transpositional activity in the presence of inhibitors. The initial emergence of the mutants was found to depend crucially upon the ...Continue Reading

References

Sep 21, 1979·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·S J Gould, R C Lewontin
Feb 1, 1990·Agricultural and Biological Chemistry·Y KurusuH Yukawa
Jan 1, 1969·Canadian Journal of Microbiology·B Skowronski, G A Strobel
Jan 29, 1981·Nature·J Cairns
Nov 15, 1994·Molecular & General Genetics : MGG·A A VertèsH Yukawa
Mar 1, 1993·Research in Microbiology·A A VertèsH Yukawa
Nov 18, 1993·Nature·S J Gould, N Eldredge
Sep 8, 1998·Microbiology and Molecular Biology Reviews : MMBR·J Mahillon, M Chandler
Mar 31, 1999·Proceedings of the National Academy of Sciences of the United States of America·D PapadopoulosM Blot
Jan 27, 2000·Archives of Microbiology·T R GarbeH Yukawa
Sep 4, 2001·Zeitschrift Für Naturforschung. C, a Journal of Biosciences·T R Garbe, H Yukawa
Aug 2, 2002·Toxicological Sciences : an Official Journal of the Society of Toxicology·Lisa M KamendulisJames E Klaunig

❮ Previous
Next ❯

Citations

Dec 8, 2005·Applied and Environmental Microbiology·Alain A VertèsHideaki Yukawa
Dec 8, 2005·Applied and Environmental Microbiology·Nobuaki SuzukiHideaki Yukawa

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.