Inhibitor of differentiation 1 transcription factor promotes metabolic reprogramming in hepatocellular carcinoma cells

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Bal Krishan SharmaAnde Satyanarayana

Abstract

Reprograming of metabolism is one of the central hallmarks of cancer. The majority of cancer cells depend on high rates of glycolysis and glutaminolysis for their growth and survival. A number of oncogenes and tumor suppressors have been connected to the regulation of altered glucose and glutamine metabolism in cancer cells. For example, the oncogene c-Myc plays vital roles in cancer cell metabolic adaptation by directly regulating various genes that participate in aerobic glycolysis and glutaminolysis. Inhibitor of differentiation 1 (Id1) is a helix-loop-helix transcription factor that plays important roles in cell proliferation, differentiation, and cell fate determination. Overexpression of Id1 causes intestinal adenomas and thymic lymphomas in mice, suggesting that Id1 could function as an oncogene. Despite it being an oncogene, whether Id1 plays any prominent role in cancer cell metabolic reprograming is unknown. Here, we demonstrate that Id1 is strongly expressed in human and mouse liver tumors and in hepatocellular carcinoma (HCC) cell lines, whereas its expression is very low or undetectable in normal liver tissues. In HCC cells, Id1 expression is regulated by the MAPK/ERK pathway at the transcriptional level. Knockdown...Continue Reading

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Citations

Jan 23, 2016·Journal of Cellular Physiology·Angela Maria Di FrancescoMaria Ausiliatrice Puglisi
Mar 1, 2017·Journal of Cellular and Molecular Medicine·Hengqiang ZhaoTao Yin
Apr 1, 2017·Genes·Himalee S SabnisKevin D Bunting
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Jun 24, 2017·Scientific Reports·Christoph MetzendorfMartina U Muckenthaler
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Jul 24, 2020·Computational Biology and Chemistry·Jarmila Nahálková
Oct 1, 2021·Pathology Oncology Research : POR·Muhammad Ihtisham UmarXianju Huang

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