Inhibitor sensitivity of respiratory complex I in human platelets: a possible biomarker of ageing

FEBS Letters
M Merlo PichG Lenaz

Abstract

NADH-Coenzyme Q reductase was assayed in platelet mitochondrial membranes obtained from 19 pools of two venous blood samples from female young (19-30 years) individuals and 18 pools from aged ones (66-107 years). The enzyme activities were not significantly changed in the two groups, but a decrease of sensitivity to the specific inhibitor, rotenone, occurred in a substantial number of aged individuals. The results are in agreement with the predictions of the mitochondrial theory of ageing and may be used to develop a sensitive biomarker of the ageing process.

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Citations

Jan 23, 1999·BioFactors·G LenazC Bovina
Apr 17, 2007·Journal of Bioenergetics and Biomembranes·Jie XuDavid T Yew
May 5, 2001·Mechanisms of Ageing and Development·M D'AurelioG Lenaz
Jun 11, 1998·Mechanisms of Ageing and Development·G BiaginiD Xin
Jan 6, 2000·Experimental Gerontology·M DrouetM H Ratinaud
May 9, 2006·Antioxidants & Redox Signaling·Giorgio LenazGiancarlo Solaini
Nov 26, 2010·Critical Care : the Official Journal of the Critical Care Forum·Fredrik SjövallEskil Elmér
Apr 16, 2011·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Maria I C Gyongyossy-Issa
May 9, 2002·Biochimica Et Biophysica Acta·Barbara VenturaGiorgio Lenaz
Dec 9, 2010·The International Journal of Neuroscience·Mohita ShrivastavaTaposh K Das
May 6, 2004·Annals of the New York Academy of Sciences·Maria Luisa GenovaGiorgio Lenaz
May 11, 2004·Movement Disorders : Official Journal of the Movement Disorder Society·Meltem MüftüogluNazmi Ozer
May 28, 2008·Journal of Microscopy·V K RamanujanB A Herman
Jun 19, 1998·Biochimica Et Biophysica Acta·G Lenaz
Aug 26, 1998·Biochimica Et Biophysica Acta·G Lenaz
Sep 27, 2000·Biochimica Et Biophysica Acta·G LenazG Parenti Castelli
Feb 21, 2006·Parkinsonism & Related Disorders·Amie L PhinneyBenjamin Drukarch
Apr 21, 2007·Methods in Cell Biology·Francesco Pallotti, Giorgio Lenaz
Apr 27, 2002·Annals of the New York Academy of Sciences·Giorgio LenazBarbara Ventura
Apr 24, 2003·Experimental Biology and Medicine·Maria Luisa GenovaGiorgio Lenaz
Jun 2, 2018·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·L HolperJ J Mann

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