PMID: 2509671Jan 1, 1989Paper

Inhibitors and activators of fibrinolysis during and after childbirth in maternal and cord blood

Journal of Perinatal Medicine
I B RunnebaumJ Bonnar

Abstract

During normal childbirth profound changes in the fibrinolytic system take place. Tissue plasminogen activator (t-PA), the antigen and its biological activity and, the activity of plasminogen activator inhibitor (PAI): were measured in twenty-two healthy women during and shortly after spontaneous delivery (2nd stage and 3rd stage of labour, 48 and 72 hours post partum). Significant increases of plasma t-PA antigen and activity occurred during childbirth and before delivery of the placenta, while the inhibitor remained unchanged. After delivery the PA inhibitor and t-PA antigen showed a steep decline. The activity of t-PA remained largely unchanged during labour and after delivery. The comparison between the activity levels of PAI in infant cord blood and in maternal peripheral blood, taken simultaneously during the process of placental separation, showed significantly higher PAI activity in the mother. In contrast the levels of t-PA activity were found to be significantly higher in cord blood. Our results demonstrate that during the process of child-birth and separation of the placenta distinct alterations in the fibrinolytic system occur most likely due to placental effects.

References

Mar 1, 1987·British Journal of Haematology·S MackinnonJ J Walker
Jan 1, 1985·Gynecologic and Obstetric Investigation·T DahlmanM Blombäck
Dec 1, 1966·American Journal of Obstetrics and Gynecology·F BellerM D Epstein
Jan 1, 1970·Acta paediatrica Scandinavica·H EkelundI M Nilsson
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Sep 15, 1982·Thrombosis Research·M RånbyP Wallén
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Citations

Jun 30, 1994·European Journal of Obstetrics, Gynecology, and Reproductive Biology·H A BremerH C Wallenburg
Sep 1, 1996·European Journal of Obstetrics, Gynecology, and Reproductive Biology·M KolbenH Tschesche
Apr 1, 1991·Baillière's Clinical Haematology·M Andrew
Dec 1, 1992·Thrombosis Research·A A SalehE F Mammen
Oct 22, 2002·American Journal of Obstetrics and Gynecology·Eva Maria RoesEric A Steegers
Apr 23, 2015·Nursing for Women's Health·Mayri Sagady Leslie
Mar 1, 1995·American Journal of Obstetrics and Gynecology·H A BremerH C Wallenburg
Oct 21, 2020·Anesthesia and Analgesia·Alexander J Butwick

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