Inhibitors for cholesterol ester accumulation in macrophages from Chinese cabbage

Bioscience, Biotechnology, and Biochemistry
Haruka TakamotoSachiko Tsukamoto

Abstract

The cholesterol ester accumulates in macrophages in the early stage of atherosclerotic lesions, leading to the formation of foam cells. We examined the inhibitory effects of the crude extracts of 22 edible plants on foam cell formation and isolated nine chlorophyll derivatives as potent inhibitors from Chinese cabbage. The results of the present study suggest that the chlorophyll derivatives contained in edible plants may be useful for the prevention and treatment of atherosclerosis.

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Citations

Nov 26, 2015·Chemistry : a European Journal·Shinji TadanoHayato Ishikawa

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Methods Mentioned

BETA
density gradient centrifugation
column chromatography
gel-filtration

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