Abstract
Endogenous renal dopamine is a major physiological regulator of renal ion transport; however its intracellular signaling pathways are not thoroughly understood. The present study examined the role of 20-hydroxyeicosatetraenoic acid (20-HETE), the major cytochrome P450 (CYP4A) metabolite of arachidonic acid formed in the renal cortex, on the natriuretic response to dopamine in Sprague Dawley rats. Infusion of dopamine (1.5μg/kg/min, i.v.) increased urine flow (1.9 fold over basal), sodium excretion (UNaV, 2.7 fold), fractional sodium excretion (FENa, 3.3 fold) and proximal and distal delivery of sodium by 1.5- and 2-fold respectively. Administration of two inhibitors of the synthesis of 20-HETE, 1-aminobenzotriazole (ABT) and N-hydroxy-N'-(-4-butyl-2-methylphenyl)formamidine (HET0016) reduced the response to dopamine by 65%. Induction of the renal expression of CYP4A enzymes with clofibrate did not alter the response to dopamine. The natriuretic response to dopamine was lower in Dahl salt-sensitive rats in comparison to an SS.BN5 consomic strain in which transfer of chromosome 5 from Brown Norway to Dahl salt-sensitive rats upregulates the renal expression of CYP4A protein and the production of 20-HETE. Treatment with HET0016 bl...Continue Reading
References
Jun 1, 1989·Hypertension·S S HegdeM F Lokhandwala
May 1, 1984·Hypertension·J C RoosH G Langford
Jun 1, 1993·Hypertension·A NishiA Aperia
Jun 1, 1993·Hypertension·R J RomanB Markham
Jan 1, 1997·Hypertension·Z Q WangR M Carey
Mar 15, 1997·The Journal of Clinical Investigation·S NowickiA Aperia
Feb 7, 1998·Hypertension·M Alonso-GaliciaR J Roman
May 26, 2001·British Journal of Pharmacology·N MiyataK Kameo
Jul 23, 2003·Hypertension·Kimberly M HoaglandRichard J Roman
Aug 2, 2003·European Journal of Pharmacology·Jay S GriderBrian A Jackson
Jan 13, 2004·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Tsuneo IshizukaSadayoshi Ito
Mar 20, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Elisabete A Dos SantosRichard J Roman
Sep 6, 2005·Seminars in Nephrology·Carlos H PedemonteAlejandro M Bertorello
Sep 16, 2005·Psychopharmacology·Abesh Kumar BhattacharjeeStanley I Rapoport
Jan 11, 2007·Hypertension·Jan M WilliamsRichard J Roman
Feb 1, 2007·American Journal of Physiology. Renal Physiology·Carolina KirchheimerSusana Nowicki
Feb 17, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ming YuRichard J Roman
Jul 16, 2008·Current Hypertension Reports·Anees Ahmad Banday, Mustafa F Lokhandwala
Oct 10, 2008·American Journal of Physiology. Renal Physiology·Jan Michael WilliamsRichard J Roman
Mar 31, 2009·Clinical and Experimental Hypertension : CHE·Chunyu ZengPedro A Jose
Feb 26, 2010·American Journal of Physiology. Renal Physiology·I Alexandru BobulescuOrson W Moe
Oct 12, 2010·Journal of Cardiovascular Pharmacology·Jan M WilliamsRichard J Roman
Nov 26, 2010·Hypertension·Chunyu Zeng, Pedro A Jose
Jun 3, 2011·Current Hypertension Reports·Mohammad AsgharTahir Hussain
Jun 28, 2011·The Journal of Clinical Investigation·Ming-Zhi ZhangRaymond C Harris
Mar 24, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jan M WilliamsRichard J Roman
Citations
Nov 27, 2014·Current Opinion in Nephrology and Hypertension·Fan FanRichard J Roman
Jun 13, 2014·Physiological Reports·Cecilia ColomberoSusana Nowicki
May 1, 2015·American Journal of Physiology. Renal Physiology·Luis A Di CianoFernando R Ibarra
Jan 17, 2015·Current Opinion in Nephrology and Hypertension·Ming-Zhi Zhang, Raymond C Harris
Oct 25, 2013·American Journal of Physiology. Renal Physiology·Ming-Zhi ZhangRaymond C Harris