Inhibitors of apoptosis proteins in human cervical cancer

BMC Cancer
Magali EspinosaJorge Melendez-Zajgla

Abstract

It has been shown that IAPs, in particular XIAP, survivin and c-IAP1, are overexpressed in several malignancies. In the present study we investigate the expression of c-IAP1, c-IAP2, XIAP and survivin and its isoforms in cervical cancer. We used semiquantitative RT-PCR assays to analyze 41 cancer and 6 normal tissues. The study included 8 stage I cases; 16 stage II; 17 stageIII; and a control group of 6 samples of normal cervical squamous epithelial tissue. c-IAP2 and XIAP mRNA levels were similar among the samples, cervical tumors had lower c-IAP1 mRNA levels. Unexpectedly, a clear positive association was found between low levels of XIAP and disease relapse. A log-rank test showed a significant inverse association (p = 0.02) between XIAP expression and tumor aggressiveness, as indicated by disease relapse rates. There were no statistically significant differences in the presence or expression levels of c-IAP1 and c-IAP2 among any of the clinical variables studied. Survivin and its isoforms were undetectable in normal cervical tissues, in contrast with the clear upregulation observed in cancer samples. We found no association between survivin expression and age, clinical stage, histology or menopausal state. Nevertheless, we f...Continue Reading

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Citations

Aug 16, 2011·Molecular Pharmaceutics·Hamidreza Montazeri AliabadiHasan Uludağ
Feb 19, 2011·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Lyliana Coutinho Resende BarbosaJulisa Chamorro Lascasas Ribalta
May 24, 2013·Investigative Radiology·Cedric M PanjeJürgen K Willmann
Sep 20, 2007·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·H FutakuchiS Noda
Apr 23, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Pablo E Vivas-MejiaGabriel Lopez-Berestein
Oct 28, 2006·BMC Cancer·Abril Arellano-LlamasJorge Melendez-Zajgla
Nov 22, 2007·Expert Opinion on Therapeutic Targets·Emma J DeanCaroline Dive
Aug 25, 2016·International Journal of Molecular Sciences·Shaobing ChengShusen Zheng
Dec 13, 2006·International Journal of Cancer. Journal International Du Cancer·Carsten KempkensteffenSteffen Weikert
Jul 3, 2009·Biological & Pharmaceutical Bulletin·Pongpun SiripongNaoto Oku
Oct 21, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Heng-Hsiung WuHuei Lee
Oct 4, 2011·Cancer Letters·Zesong LiBenjamin C Y Wong

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Methods Mentioned

BETA
hysterectomy
PCR

Software Mentioned

SPSS

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