Inhibitors of arachidonic acid metabolism eliminate the increase in cytosolic free calcium induced by the mitogen concanavalin A in rat thymocytes

FEBS Letters
A S Gukovskaya Evtodienko YuV

Abstract

Using inhibitors of arachidonic acid (AA) metabolism, the possible involvement of AA products in the generation of [Ca2+]i and the pHi rise induced by the mitogen concanavalin A (Con A) in rat thymocytes has been studied. The lipoxygenase inhibitor nordihydroguaiaretic acid (NDGA, 10 microM) and the phospholipase A2 inhibitor bromophenacyl bromide (10 microM) eliminated the [Ca2+]i signal induced by Con A; the cyclooxygenase blocker indomethacin also inhibited it. However, neither NDGA nor indomethacin suppressed the pHi rise stimulated by Con A. Exogenous AA induced an increase in [Ca2+]i but not in the pHi. These results indicate that AA metabolites, probably of the lipoxygenase pathway, take part in the generation of the [Ca2+]i response to the mitogen. In contrast, they appear not to be involved in the pHi rise evoked by Con A.

References

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Citations

Oct 19, 1992·Biochimica Et Biophysica Acta·A S GukovskayaV V Bezuglov
Jan 1, 1992·Prostaglandins, Leukotrienes, and Essential Fatty Acids·P P Lee, M M Ip
Oct 1, 1993·Biulleten' eksperimental'noĭ biologii i meditsiny·E I AstashkinA S Dukhanin

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