Inhibitors of BCATm: A Tough Nut To Crack

Journal of Medicinal Chemistry
Martin Scanlon

Abstract

Inhibitors of the mitochondrial branched chain aminotransferase may have therapeutic potential in the treatment of diet-induced obesity and dyslipidemia. To explore the pharmacology of this metabolic pathway requires a potent and selective molecule that is well tolerated and has appropriate pharmacokinetic properties. The combination of fragment-based and high-throughput screening with structure-guided compound elaboration has yielded a tool compound that may serve as a chemical probe of this pathway.

References

Feb 1, 2014·Nature Reviews. Drug Discovery·Andrew L HopkinsCharles H Reynolds
Jul 22, 2015·Nature Chemical Biology·Cheryl H ArrowsmithWilliam J Zuercher
Aug 20, 2015·ACS Medicinal Chemistry Letters·Hongfeng DengQuan Zhou

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Citations

Apr 5, 2017·ACS Combinatorial Science·M G Finn
Apr 14, 2017·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Heather M JosephMichele D Levine
Jun 14, 2018·Social Cognitive and Affective Neuroscience·Lisa J M van den BergBernet M Elzinga
Jan 13, 2017·Journal of Medicinal Chemistry·Stevan W Djuric, Nicholas A Meanwell

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