PMID: 9436466Jun 1, 1997Paper

Inhibitors of dipeptidyl peptidase IV (DP IV, CD26) induces secretion of transforming growth factor-beta 1 (TGF-beta 1) in stimulated mouse splenocytes and thymocytes

Immunology Letters
D ReinholdS Ansorge

Abstract

Various studies have shown that the ectoenzyme dipeptidyl peptidase IV (DP IV, CD26), expressed on T, NK and B cells in the human immune system, is involved in the regulation of DNA synthesis and cytokine production. The DP IV/CD26 was found also on mouse splenocytes and thymocytes. Here, we show that the specific DP IV inhibitors Lys[Z(NO2)]-thiazolidide, Lys[Z(NO2)]-pyrrolidide inhibit DNA synthesis as well as production of IL-2, IL-6 and IL-10 of PHA-stimulated mouse splenocytes and Con A-stimulated mouse thymocytes. Most importantly, these inhibitors induce a three to fourfold increased secretion of latent transforming growth factor beta 1 (TGF-beta 1) by mitogen-stimulated mouse immune cells, as measured with a specific TGF-beta 1 enzyme-linked immunosorbent assay (ELISA). These data demonstrate that CD26 plays a role also in regulation of DNA synthesis and cytokine production by murine immune cells, that the enzymatic activity is required for mediating these effects, and that TGF-beta 1 might have key functions in these processes.

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Citations

Feb 27, 2010·Inflammatory Bowel Diseases·Roger YazbeckCatherine A Abbott
Aug 4, 1999·Immunology Today·D ReinholdS Ansorge
May 6, 2008·Trends in Immunology·Kei OhnumaChikao Morimoto
Oct 4, 2007·Annals of the New York Academy of Sciences·Dirk ReinholdStefan Brocke
Aug 14, 2009·Clinical Chemistry and Laboratory Medicine : CCLM·Dirk ReinholdUte Bank
Jun 16, 2015·Journal of Diabetes Research·Jixin ZhongSanjay Rajagopalan
Aug 27, 2016·Clinical Reviews in Allergy & Immunology·Juan J Nieto-FontarigoFrancisco J Salgado
Jan 10, 2017·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Marcelo Maia PinheiroSusana Nogueira Diniz
Sep 30, 2015·Diabetes/metabolism Research and Reviews·Wenjia YangLinong Ji
Jul 14, 2011·Journal of Cellular Biochemistry·Lara BaticicJadranka Varljen
Sep 18, 2013·Diabetes, Obesity & Metabolism·C Evans-MolinaR G Mirmira
Jan 23, 2020·Emerging Microbes & Infections·Hannah Kleine-WeberMarkus Hoffmann
Feb 27, 2016·Clinical and Experimental Immunology·C KlemannS von Hörsten
Feb 13, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·A SteinbrecherS Brocke
May 2, 2018·Immunology Letters·Munkyung KimIwona Ksiazek
Mar 22, 2003·European Journal of Cell Biology·Emil Boonacker, Cornelis J F Van Noorden

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