Inhibitors of leukotriene A4 (LTA4) hydrolase as potential anti-inflammatory agents

Current Pharmaceutical Design
T D Penning

Abstract

Leukotriene A4 (LTA4) hydrolase is a zinc-containing enzyme which stereospecifically catalyzes the hydrolysis of the epoxide LTA4 to the diol leukotriene B4 (LTB4). There is substantial evidence that LTB4 plays a significant role in the amplification of many inflammatory disease states. Therapeutic agents which selectively inhibit LTA4 hydrolase would block the formation of LTB4 and thus be potentially useful for the treatment of inflammation. Numerous inhibitors of LTA4 hydrolase have been reported over the past 15-20 years. Several early inhibitors were based on the structure of the natural substrate, LTA4. Later approaches utilized known inhibitors of related zinc-containing metalloproteinases and led to the identification of captopril, bestatin and kelatorphan as potent inhibitors of LTA4 hydrolase. This led to the design of a number of peptide and non-peptide analogs which contained potential zinc-chelating moieties, including thiols, hydroxamates and norstatines. A more recent series of non-peptidic, non-zinc chelating inhibitors of LTA4 hydrolase has been reported. This work led to the identification of several novel classes of analogs, including imidazopyridines, amidines and cyclic and acyclic amino acid derivatives, u...Continue Reading

Citations

Jul 17, 2003·Journal of the National Cancer Institute·Xiaoxin ChenChung S Yang
May 7, 2008·Infection and Immunity·Daniel P MacEachranGeorge A O'Toole
Oct 26, 2012·Expert Opinion on Drug Discovery·Burcu Calışkan, Erden Banoglu
Oct 1, 2008·Bioorganic & Medicinal Chemistry Letters·Michael B HarbutDoron C Greenbaum
Mar 8, 2005·Progress in Lipid Research·John W NewmanBruce D Hammock
Oct 5, 2013·Expert Opinion on Therapeutic Targets·Antonio Di Gennaro, Jesper Z Haeggström
Jul 6, 2014·Methods : a Companion to Methods in Enzymology·Ingo Muegge, Qiang Zhang
Jul 2, 2008·Bioorganic & Medicinal Chemistry Letters·Seock-Kyu KhimWilliam J Guilford
Jul 1, 2008·Bioorganic & Medicinal Chemistry Letters·Bin YeWilliam J Guilford
Mar 21, 2007·The Journal of Pharmacology and Experimental Therapeutics·Navin L RaoAnne M Fourie
Sep 19, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Marjolein M G M ThunnissenJesper Z Haeggström
Jun 1, 2018·Journal of Immunology Research·A KovtunA Ignatius
Jun 26, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Suaad A AudatQosay A Al-Balas
Aug 16, 2018·The Journal of Clinical Investigation·Jesper Z Haeggström
Jun 18, 2009·Cancer Research·Chul-Ho JeongZigang Dong
Sep 23, 2011·Chemical Reviews·Jesper Z Haeggström, Colin D Funk
Apr 9, 2008·Bioorganic & Medicinal Chemistry·Thomas A KirklandWilliam J Guilford
Oct 28, 2008·Bioorganic & Medicinal Chemistry Letters·Xiaolu JiangLuhua Lai
Apr 8, 2010·Bioorganic & Medicinal Chemistry Letters·Vincent SandanayakaJasbir Singh

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here