PMID: 8592060Jan 1, 1996Paper

Inhibitors of nitric oxide synthase in human skin

The Journal of Investigative Dermatology
P C GoldsmithJ C Foreman

Abstract

The aim of this study was to investigate in human skin in vivo the role of nitric oxide in maintaining resting vascular tone, in the vasodilatation caused by local warming and by ultraviolet B light exposure, and in the response to exogenous calcitonin gene-related peptide (CGRP). Cutaneous blood flow was assessed by planimetry of the visible erythema or pallor and by laser Doppler flowmetry. Intradermal injection of the inhibitor of nitric oxide synthase, NG-nitro-L-arginine methyl ester (L-NAME; 25 nmol), into forearm skin produced a visible pallor and a reduction of blood flow at a controlled ambient temperature of 21 degrees C. The control, NG-nitro-D-arginine methyl ester (D-NAME; 25 nmol) or NG-monomethyl-L-arginine (L-NMMA; 25 nmol) did not cause pallor or reduce blood flow. L-NAME and L-NMMA caused dose- and time-dependent increases in pallor, and reductions in cutaneous blood flow in skin that had been locally warmed by immersion in water at 45 degrees C and in skin that had been exposed to ultraviolet B light. D-NAME and D-NMMA at comparable concentrations did not have the effects on skin blood flow observed with the L forms. L-NAME and L-NMMA both inhibited the increased blood flow in human skin caused by the intrade...Continue Reading

Citations

Jan 13, 2004·Journal of Applied Physiology·J L ZhaoD L Kellogg
Jun 3, 2008·European Journal of Applied Physiology·Helena Lenasi, Martin Strucl
Jun 10, 2009·Journal of Burn Care & Research : Official Publication of the American Burn Association·Scott L DavisCraig G Crandall
Jun 11, 2009·Clinical and Experimental Dermatology·C ZinelliD J Atherton
Jan 16, 2013·Journal of Cardiovascular Pharmacology·Céline DreyfussJean François Argacha
Dec 6, 2012·International Journal of Endocrinology·Luís UvaPaulo Filipe
Apr 8, 1999·Journal of Applied Physiology·D L KelloggD O'Donnell
Aug 12, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G Clough
Sep 8, 1998·Journal of Applied Physiology·D L KelloggJ M Johnson
Jul 29, 2006·Journal of Cutaneous Pathology·Thaís P Amadeu, Andréa M A Costa
Oct 1, 2005·Journal of Applied Physiology·Brett J WongChristopher T Minson
Jan 25, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Ilkka HeinonenHellsten Ylva
Mar 4, 2000·European Journal of Pain : EJP·R T Hoffmann, M Schmelz
Jun 28, 2000·Current Opinion in Clinical Nutrition and Metabolic Care·D T EfronA Barbul
Jun 21, 2007·British Journal of Clinical Pharmacology·B J Van der SchuerenS R Sinclair
Feb 26, 2003·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Ronald WolfUlrike Blume-Peytavi
Mar 25, 2010·The British Journal of Dermatology·S AbeyakirthiR B Weller
Jan 25, 2008·The Journal of Pharmacology and Experimental Therapeutics·B J Van der SchuerenJ N de Hoon
Mar 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Kozo NakaiRonald P Mason
Jun 10, 2005·Psychophysiology·Marie-Jo Brion, Peter D Drummond
Mar 14, 2002·Nitric Oxide : Biology and Chemistry·Birgit StallmeyerStefan Frank
Mar 17, 1997·Biochemical and Biophysical Research Communications·N AhmadH Mukhtar
Feb 11, 1998·General Pharmacology·P Holzer
Nov 5, 1997·Journal of Pain and Symptom Management·M Anbar, B M Gratt
Jan 10, 1998·The Journal of Investigative Dermatology·D Bruch-GerharzV Kolb-Bachofen
May 3, 2003·Journal of Dermatological Science·Kozo NakaiHiroaki Kosaka
Oct 15, 2003·Burns : Journal of the International Society for Burn Injuries·Andrew Rawlingson
Jan 10, 1998·British Journal of Plastic Surgery·O GribbeN P Wiklund
Jul 28, 2004·Nitric Oxide : Biology and Chemistry·M-M Cals-Grierson, A D Ormerod
Jul 15, 1998·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·M Anbar, B M Gratt
Apr 1, 1996·The Journal of Investigative Dermatology·H A BullP M Dowd
Sep 1, 1996·The Journal of Investigative Dermatology·R WellerN Benjamin
Nov 3, 2009·Nitric Oxide : Biology and Chemistry·Christoph V SuschekErnst E van Faassen
Jul 30, 2019·Skin Pharmacology and Physiology·Sung Min Pyo, Howard I Maibach

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.