PMID: 11907187Mar 22, 2002Paper

Inhibitors of pentose phosphate pathway cause vasodilation: involvement of voltage-gated potassium channels

The Journal of Pharmacology and Experimental Therapeutics
Sachin A GupteMasahiko Oka

Abstract

Cytosolic reducing cofactors, such as NADPH and NADH, are thought to regulate vascular smooth muscle ion channel activity and vascular tone. In this study, the effects of pentose phosphate pathway (PPP) inhibitors, 6-aminonicotinamide (6-AN), epiandrosterone (EPI), and dehydroepiandrosterone (DHEA), on vascular tone were studied in isolated perfused lungs and pulmonary artery (PA) and aortic rings from rats. In addition, effects of 6-AN on voltage-gated K(+) (K(v)) current in PA smooth muscle cells (SMCs) were also examined. Pretreatment of lungs with 6-AN and EPI reduced the pressor response to acute hypoxia and decreased tissue NADPH levels. 6-AN, EPI, and DHEA relaxed isolated PA and aortic rings precontracted with 30 mM KCl in a dose-dependent manner. The PPP inhibitor-induced PA relaxations were reduced in PA rings precontracted with 80 mM KCl but not by pretreatment with nitro-L-arginine or endothelial removal. Pretreatment of PA rings with tetraethylammonium chloride or 4-aminopyridine caused rightward shifts of concentration-relaxation curves for 6-AN, EPI, and DHEA. In contrast, glybenclamide, charybdotoxin, or apamin did not inhibit the relaxant effects of 6-AN, EPI, and DHEA. 6-AN caused an increase in K(v) current i...Continue Reading

References

Apr 1, 1995·Archives of Biochemistry and Biophysics·G GordonH R Levy
Apr 1, 1995·The American Journal of Physiology·M T Nelson, J M Quayle
Feb 1, 1995·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·E K Weir, S L Archer
Feb 15, 1995·Circulation·P YueP Collins
Jun 1, 1994·Pflügers Archiv : European journal of physiology·S LeeY E Earm
Apr 1, 1999·American Journal of Respiratory Cell and Molecular Biology·W PengI S Farrukh
Nov 11, 1999·European Journal of Pharmacology·S SeitzH Nawrath

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Citations

Apr 7, 2010·The Journal of Biological Chemistry·Rakhee S GupteSachin A Gupte
Mar 5, 2008·Antioxidants & Redox Signaling·Sachin A Gupte, Michael S Wolin
Jul 24, 2010·Antioxidants & Redox Signaling·Rakhee S GupteSachin A Gupte
May 15, 2012·American Journal of Physiology. Lung Cellular and Molecular Physiology·Sukrutha ChettimadaSachin A Gupte
Dec 21, 2006·Respiratory Research·Edouard H DebonneuilEtienne-Emile Baulieu
Jul 25, 2003·Proceedings of the National Academy of Sciences of the United States of America·Sébastien BonnetEtienne-Emile Baulieu
May 23, 2014·The Journal of Steroid Biochemistry and Molecular Biology·M HillL Stárka
May 22, 2007·Antioxidants & Redox Signaling·Michael S WolinSachin A Gupte
Sep 10, 2013·Pulmonary Circulation·Eric D AustinMasahiko Oka
Jun 28, 2013·British Journal of Pharmacology·K M MairM R MacLean
Jun 9, 2004·Free Radical Biology & Medicine·Jordi BoadaJordi Bermudez
Sep 24, 2013·Bulletin of Environmental Contamination and Toxicology·Muhammet GulerHilal Kivrak
Oct 6, 2005·Pulmonary Pharmacology & Therapeutics·Sachin A GupteMasahiko Oka
Jul 1, 2005·European Journal of Pharmacology·Eduardo CuestaJordi Bermudez
Mar 7, 2012·Biochemical Pharmacology·M ChevalierJ P Savineau
Dec 29, 2012·Biochemical Pharmacology·Jean-Pierre SavineauEric Dumas de la Roque
Jun 24, 2017·Antioxidants & Redox Signaling·Angelo D'AlessandroKurt R Stenmark
Sep 4, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Sachin A GupteMichael S Wolin
Nov 1, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Rikuo OchiSachin A Gupte
Jun 6, 2003·Endocrine Reviews·Peter Y LiuDavid J Handelsman
Feb 3, 2012·Physiological Reviews·J T SylvesterJeremy P T Ward
Apr 16, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Abdallah AlzoubiMasahiko Oka
Dec 7, 2014·American Journal of Physiology. Lung Cellular and Molecular Physiology·Sukrutha ChettimadaSachin A Gupte
Jan 1, 2014·American Journal of Physiology. Lung Cellular and Molecular Physiology·Dhara PatelMichael S Wolin
Nov 3, 2016·American Journal of Physiology. Lung Cellular and Molecular Physiology·John C HuetschLarissa A Shimoda
May 1, 2015·International Journal of Endocrinology and Metabolism·Tiphaine MannicMichel Florian Rossier
May 23, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Rakhee GupteSachin A Gupte
Aug 23, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Sachin A GupteMichael S Wolin
Mar 25, 2021·The Journal of Pharmacology and Experimental Therapeutics·Atsushi KitagawaSachin A Gupte

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