Inhibitors of PLA2 and NO synthase cooperate in producing amnesia of a spatial task

Neuroreport
C HölscherG Richter-Levin

Abstract

Both nitric oxide and arachidonic acid have been suggested to play a role as a retrograde messenger in synaptic plastic changes which underlie memory formation. However, inhibitors of nitric oxide (NO) synthesis or of arachidonic acid release have produced contradictory results. We suggest a model which involves simultaneous release of both messenger types which can compensate for the loss of one type. To test this theory, rats were injected either with a drug that inhibits release of arachidonic acid, or a drug that inhibits synthesis of NO, or with both drugs. Acquisition of a water maze task was not different between groups. In the test sessions, however, animals injected with both drugs showed marked amnesic symptoms, while the groups injected with a low dose of nordihydroguaiaretic acid (NDGA) or with nitro-L-arginine (L-NARG) showed a trend towards amnesia. The effect of both drugs appears to be additive. The results support the proposed theory.

Citations

Oct 27, 2006·Journal of Neural Transmission·E L Schaeffer, W F Gattaz
Jun 28, 2008·Journal of Neural Transmission·Stefan SmesnyHeinrich Sauer
Feb 21, 2002·Progress in Neuro-psychopharmacology & Biological Psychiatry·Cindy M Pudiak, Michael A Bozarth
Jun 6, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·Lisa A Teather, Richard J Wurtman
Mar 28, 2002·Learning & Memory·Lisa A TeatherNicolas G Bazan
Sep 8, 2010·Experimental Neurology·Sandeep SharmaFernando Gomez-Pinilla
Aug 22, 2000·Japanese Journal of Pharmacology·S FujitaN Matsuki

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