PMID: 11314960Apr 21, 2001Paper

Inhibitors of platelet lipoxygenase from Ponkan fruit

Phytochemistry
Y NogataT Ishizu

Abstract

An activity-guided separation for inhibitors of rat platelet 12-lipoxygenase led to the isolation of two compounds, 4-O-feruloyl-5-O-caffeoylquinic acid (IC50; 5.5 microM) and methyl 4-O-feruloyl-5-O-caffeoylquinate (IC50; 1.9 microM) from the peel of Ponkan fruit (Citrus reticulata). The complete structure of each phenolic ester was determined by NMR spectroscopy [1H and 13C NMR spectra, 1H-1H correlation spectroscopy (COSY), 1H-detected heteronuclear multiple quantum coherence (HMQC), and heteronuclear multiple bond connectivity (HMBC) spectroscopies] and other spectral methods.

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Citations

Apr 20, 2006·Journal of Hazardous Materials·Flávio A PavanYoshitaka Gushikem
Jan 18, 2006·Memórias do Instituto Oswaldo Cruz·Manal A Hamed, Mona H Hetta
Feb 28, 2006·Bioorganic & Medicinal Chemistry·Joshua D DeschampsTheodore R Holman
Jul 1, 2017·Comprehensive Reviews in Food Science and Food Safety·Eliane de Oliveira Silva, Ronan Batista
Jul 4, 2003·The Journal of Organic Chemistry·Nuria ArmestoVicente Gotor
Dec 3, 2003·Journal of Agricultural and Food Chemistry·Yoichi NogataKeizo Sekiya

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