Inhibitors of the Janus Kinases: A New Oral Treatment Option for Ulcerative Colitis.

Journal of Clinical Gastroenterology
Elisabetta AntonelliGabrio Bassotti

Abstract

The treatment of ulcerative colitis (UC) is based on conventional therapies (aminosalicylates, corticosteroids, and immunosuppressants) and when these are ineffective, biologic drugs. However, in a substantial portion of patients undergoing treatment with biologic agents there is primary or secondary loss of response. Thus, new therapeutic options are been actively explored; among these, there is interest in the Janus kinase (JAK) inhibitors, small molecules that can be administered orally. We carried out an extensive literature search concerning the effects of JAK inhibitors for the treatment of patients with UC. Tofacitinib is the drug more extensively studied in this setting, and it was recently approved in Europe for the treatment of moderate to severe UC. The available data suggest that this drug can be effective in obtaining clinical and endoscopic remission in UC patients unresponsive to other treatments, even in those previously treated with biologic drugs. In addition, the drug was able to improve significantly the quality of life of these patients. There are still few data available for the treatment of UC with other JAK inhibitors. The JAK inhibitors, in particular tofacitinib, are a new class of orally administered ...Continue Reading

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Citations

Aug 3, 2020·Journal of Clinical Gastroenterology·Irene Modesto
Mar 21, 2021·Inflammatory Bowel Diseases·Isabel GarridoGuilherme Macedo

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Methods Mentioned

BETA
pharmacotherapy

Software Mentioned

OCTAVE

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