PMID: 8946218Oct 1, 1996Paper

Inhibitory action of deoxyspergualin on effector/memory T cell generation during Hymenolepis nana infection in mice

Immunology Letters
K AsanoK Okamoto

Abstract

The effects of deoxyspergualin (DSG), a newly developed immunosuppressive agent, on protective immunity to Hymenolepis nana reinfection were examined in BALB/c mice. Administration of DSG at daily doses of 10.0 mg/kg to 30.0 mg/kg (but not 5.0 mg/kg) caused suppression of protective immunity when the agent was injected intraperitoneally during the induction phase of the immunity. In contrast, daily administration of 30.0 mg/kg DSG, during effector phase, could not suppress protective immunity. DSG inhibited endogenous interferon-gamma production in mesenteric lymph nodes induced by H. nana challenge infection, when the agent was injected intraperitoneally at a daily dose of 10.0 mg/kg during the induction phase of immunity. Delayed type hypersensitivity (DTH) local transfer analysis revealed that administration of DSG at 10.0 mg/kg/day into donor mice during induction phase of immunity inhibited generation of effector/memory cells that mediate DTH to H. nana egg antigen. However, DSG could not inhibit DTH effector cell activation when cells prepared from H. nana-infected, saline-injected mice were transferred into recipient treated with 10.0 mg/kg DSG. Administration of DSG at a dose of 10.0 mg/kg daily for 5 days produced larg...Continue Reading

Citations

Jan 9, 2004·Acta Oto-laryngologica·Sumiko HiranoHarumi Suzaki
Oct 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hilda HolcombeBonnie N Dittel
Nov 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shlomit Reich-ZeligerYair Reisner

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