PMID: 2505994Aug 1, 1989Paper

Inhibitory action of gliclazide on platelet functions

Diabetes Research and Clinical Practice
A MizunoK Shima

Abstract

Gliclazide (GC), an oral hypoglycemic agent, inhibits platelet functions, but its effective concentration is reported to be much higher in vitro than in vivo. To determine why, we compared its inhibitory effect measured by impedance aggregometry using citrated whole blood with that measured by turbidometry using platelet-rich plasma. In addition, to see how GC inhibits platelet functions, we examined its effects on arachidonic acid metabolism in platelets in an in vitro system. Impedance aggregometry was found to be more sensitive than turbidometry for detecting the inhibition of platelet aggregation, and revealed significant inhibition at 1 x 10(-4) M GC. GC reduced the amount of prostaglandin I2 (PGI2) needed to inhibit ADP-induced platelet aggregation and the adhesiveness of platelets to a rabbit vessel wall after their preincubation with 1 x 10(-3) M GC for 10 min. GC (1 x 10(-4) -1 x 10(-2) M) had no effect on platelet cyclo-oxygenase activity. GC inhibited thromboxane A2 (TXA2)-induced platelet aggregation, but had no effect on the aggregation triggered by addition of mixtures of arachidonic acid (AA) and inhibitors of key enzymes regulating various steps of AA metabolism in platelets. GC had no significant effect on PGI2...Continue Reading

References

Aug 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·M HambergB Samuelsson
Jan 1, 1982·Current Medical Research and Opinion·F VioliE Vezza

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Citations

Dec 31, 2002·Adverse Drug Reactions and Toxicological Reviews·Maribel Salas, Jaime J Caro
Jan 1, 1990·Platelets·T J Hendra, J S Yudkin
Jan 1, 1991·Diabetes Research and Clinical Practice·D B CampbellC Nathan
Jan 1, 1991·Diabetes Research and Clinical Practice·O Ziegler, P Drouin
Jun 1, 2015·Journal of Diabetes and Its Complications·Athanasia PapazafiropoulouDimitri P Mikhailidis
Apr 12, 2019·Frontiers in Physiology·Cristiane Assunção da Costa Cunha MafraAurigena Antunes de Araújo
Aug 6, 2020·Frontiers in Cardiovascular Medicine·Benjamin A T Rodriguez, Andrew D Johnson
May 1, 1992·Metabolism: Clinical and Experimental·D N Brindley

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