PMID: 6277435Feb 25, 1982

Inhibitory action of the ventral noradrenergic bundle on the lateral hypothalamic neurons through alpha-noradrenergic mechanisms in the rat

Brain Research
S Miyahara, Y Oomura


Electrical stimulation of the ventral noradrenergic bundle (V-NA bundle) produced 3 types of responses in lateral hypothalamic neurons: IPSPs, a polysynaptic EPSP-IPSP sequence and antidromic spikes. The IPSPs were considered to be monosynaptic due to the fixed latencies seen at stimulus intensities. Iontophoretic application of an alpha-NA antagonist blocked only the presumed monosynaptic inhibition. Most of the glucose-sensitive neurons were inhibited by stimulation of the V-NA bundle. These results may account for the hyperphagia and obesity produced by selective lesions of the V-NA bundle.


Jan 1, 1996·Neuroscience and Biobehavioral Reviews·L L Bernardis, L L Bellinger
Oct 22, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Linda Rinaman
Jan 1, 1993·Neuroscience and Biobehavioral Reviews·L L Bernardis, L L Bellinger
Mar 30, 2007·Frontiers in Neuroendocrinology·Linda Rinaman
Dec 9, 2008·Autonomic Neuroscience : Basic & Clinical·Cristiane BusnardoFernando Morgan Aguiar Corrêa
May 13, 2017·Journal of Neurochemistry·Jinwoo ParkRohan V Bhimani


Jan 1, 1977·Annual Review of Pharmacology and Toxicology·B G Hoebel
Jan 1, 1971·Acta Physiologica Scandinavica. Supplementum·U Ungerstedt
Oct 1, 1970·Journal of Comparative and Physiological Psychology·D L Margules
May 15, 1969·Annals of the New York Academy of Sciences·Y OomuraN Kobayashi
Apr 19, 1969·Nature·Y OomuraM J Wayner

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