PMID: 2484436Jan 1, 1989Paper

Inhibitory actions of somatostatin on cyclic AMP and aldosterone production in agonist-stimulated adrenal glomerulosa cells

Cellular Signalling
W P HausdorffK J Catt

Abstract

Somatostatin (SRIF) is a potent inhibitor of angiotensin II (AII)-stimulated aldosterone production in rat adrenal glomerulosa cells. This inhibition can be prevented by pretreatment of the cells with pertussis toxin, but little else is known about either the specificity or the biochemical bases of SRIF action in this tissue. We therefore conducted detailed studies of the influence of SRIF on steroidogenesis elicited by AII and the other two physiological stimuli of aldosterone production, K+ and adrenocorticotropic hormone (ACTH), in rat adrenal glomerulosa cells. We also determined the effects of SRIF on cytosolic calcium concentration ([Ca2+]i) and cellular cAMP levels. In these studies, SRIF was found to inhibit the aldosterone responses elicited by low concentrations of all three stimuli, which are believed to promote steroid secretion via discrete but interacting cellular signalling mechanisms. In addition, SRIF consistently lowered cellular cAMP levels in the presence of each of the three agents. However, SRIF caused a small and transient increase rather than a decrease in basal ([Ca2+]i), and had no effect on the subsequent elevation of ([Ca2+]i) by AII and K+. These data indicate that activation of a Gi-like protein by...Continue Reading

References

Dec 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·D L LewisA Luini
Apr 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·C J CohenH Rasmussen
Jun 1, 1985·Molecular and Cellular Endocrinology·P EnyediA Spät
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Dec 3, 2008·Cancer Research·Takahiro IshiguroHisafumi Yamada-Okabe

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Citations

Apr 1, 1993·The Journal of Steroid Biochemistry and Molecular Biology·G Aguilera
Mar 15, 2005·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·John F LeatherlandRick Renaud
Jan 23, 2016·Journal of Molecular Endocrinology·Nicole Gallo-Payet
Nov 5, 1997·The Journal of Clinical Endocrinology and Metabolism·G P RossiG G Nussdorfer

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