Inhibitory activities of acteoside, isoacteoside, and its structural constituents against protein glycation in vitro

Botanical Studies
Yuh-Hwa LiuWen-Chi Hou

Abstract

Advanced glycation end products (AGE) are substances that can induce insulin resistance in adipocyte, hepatocyte and muscle cells. This resistance correlates highly with cardiovascular disease and diabetic complications. Acteoside (A), a phenylethanoid glycoside, is an active compound in several plants and traditional herbal medicines. Acteoside, its structural isomer, isoacteoside (I), and their constituents, caffeic acid (C) and 3,4-dihydroxyphenylethanol (D), were used in the study to investigate the inhibitory activity against AGE formations in vitro. AGE formations were detected by anti-(N(ϵ)-(carboxymethyl)lysine (anti-CML), using bovine serum albumin (BSA)/glucose (glc) and BSA/galactose (gal) as models, or by anti-argpyrimidine (anti-AP), using BSA/methylglyoxal (MGO) as models. It was found that A, I, C, or D, each at 5 mM, could attenuate the CML formations detected by ELISA in the BSA/gal model of a 3-day or 5-day reaction, and showed significant differences (P < 0.01 or P < 0.001) compared to the control. However, these compounds showed a minor effect after a 7-day incubation. It was also found that C or D could lower the CML formations in the BSA/glc model and showed significant differences (P < 0.05 or P < 0.01) c...Continue Reading

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Citations

Aug 12, 2020·Medicinal Research Reviews·Lipeng WuBaiyi Lu
Dec 2, 2014·Natural Product Research·Jabeena KhazirHalmuthur Mahabalarao Sampath Kumar
Nov 14, 2021·Comprehensive Reviews in Food Science and Food Safety·Joana MadureiraLillian Barros

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Methods Mentioned

BETA
electrophoresis
enzyme-linked immunosorbent assay
ELISA

Software Mentioned

GeneSys
GraphPad Prism
GeneTools

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