PMID: 9191018May 1, 1997Paper

Inhibitory activity of 3'-fluoro-2' deoxythymidine and related nucleoside analogues against adenoviruses in vitro

Antiviral Research
R MentelE Matthes

Abstract

Antiviral effects of nucleoside analogues against human adenoviruses (ADV) belonging to subgroup B (ADV3) and C (ADV2) were comparatively analysed using focus reduction assay on Fogh and Lund (FL) cells. 3'-Fluoro-2'-deoxythymidine (FTdR), 3'-fluoro-2'-deoxyuridine (FUdR), 2',3'-dideoxycytidine (ddC) and 3'-fluoro-2'-deoxyguanosine (FGdR) emerged as potent and selective inhibitors. They were nontoxic for the FL cells at the tested doses. FTdR was proved to be the most effective inhibitor against both serotypes ADV2 and ADV3 (0.05 microM/0.02 microM). The inhibitory effect of FTdR was also analyzed on the level of viral proteins and viral DNA synthesis using radioimmunoprecipitation and PCR, respectively. Neither the main structural protein of ADV, the hexon, nor viral DNA could be detected in ADV-infected FL cells that had been exposed to FTdR.

References

Jun 1, 1992·AIDS Research and Human Retroviruses·R F SchinaziP M Feorino
Oct 1, 1990·Antimicrobial Agents and Chemotherapy·E MatthesW E Müller
Jun 16, 1988·Biochemical and Biophysical Research Communications·E MatthesP Langen
Nov 15, 1988·Biochemical and Biophysical Research Communications·S SuzukiD L Tyrrell
May 29, 1987·Biochemical and Biophysical Research Communications·J BalzariniE De Clercq
Jun 1, 1993·The Journal of Infectious Diseases·J A JerniganB M Farr
Jan 1, 1996·Journal of Virological Methods·R JacksonA B Tullo
May 1, 1996·Journal of Virological Methods·R MentelU Wegner

❮ Previous
Next ❯

Citations

Jan 18, 2007·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Eiichi UchioShigeaki Ohno
Dec 13, 2003·Antiviral Research·Hisatoshi KanekoTatsuo Suzutani
Jul 13, 2001·Antiviral Research·A Ruzindana-Umunyana, J M Weber
Oct 25, 2001·Antiviral Research·H KanekoS Shigeta
Jun 22, 2002·Antiviral Research·L C ChiangC C Lin
Jun 22, 2002·Antiviral Research·Paul J HippenmeyerDavid W Griggs
May 14, 2003·Antiviral Research·Joseph M WeberSucheta Sircar
Mar 12, 2013·Nucleosides, Nucleotides & Nucleic Acids·Eric R SamuelsAhmed M Awad
Jul 15, 2006·Nucleosides, Nucleotides & Nucleic Acids·Takayoshi ToriiErik De Clercq
Jun 29, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Michael G Ison
Feb 21, 2008·Antimicrobial Agents and Chemotherapy·Parmjeet RandhawaMatthews Bradley
Feb 25, 2005·Antimicrobial Agents and Chemotherapy·L NaesensErik De Clercq
May 16, 2006·Antiviral Research·L Lenaerts, L Naesens
Jul 26, 2008·Reviews in Medical Virology·Liesbeth LenaertsLieve Naesens
May 28, 2005·The Journal of Antimicrobial Chemotherapy·Osmond J D'Cruz, Fatih M Uckun
Feb 21, 2007·Journal of Chemotherapy·V V ZarubalevL I Palchikovskaya
Jan 1, 2014·Living Reviews in Relativity·Hubert F M Goenner
Mar 4, 2005·The Journal of Antimicrobial Chemotherapy·Paul R KinchingtonY Jerold Gordon
Aug 28, 2020·Microorganisms·Bratati Saha, Robin J Parks

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.