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Inhibitory activity of analogues of luteinizing hormone-releasing hormone (LH-RH) in vitro and in vivo

Clinical Endocrinology

Jan 1, 1976

L H FerlandA V Schally

PMID: 802684

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Abstract

Improved inhibitors of LH-RH are those which, beside removal of the histidine residue at position 2 of LH-RH, include replacement of glycine at position 6 by a D-amino acid. A still better modification is replacement of the histidine residue at position 2 by D-phenylalanine. As examples...read more

Mentioned in this Paper

Pituitary Hormone Suppressant
Amino Acid [EPC]
Recombinant Gonadorelin
Analog
Dose-Response Relationship, Drug
Gonadorelin Hydrochloride
GNRH1 gene
Luteozyman
Metabolic Inhibition
Structure-Activity Relationship
Paper Details
References
  • References10
  • Citations2
1

Inhibitory activity of analogues of luteinizing hormone-releasing hormone (LH-RH) in vitro and in vivo

Clinical Endocrinology

Jan 1, 1976

L H FerlandA V Schally

PMID: 802684

DOI:

Abstract

Improved inhibitors of LH-RH are those which, beside removal of the histidine residue at position 2 of LH-RH, include replacement of glycine at position 6 by a D-amino acid. A still better modification is replacement of the histidine residue at position 2 by D-phenylalanine. As examples...read more

Mentioned in this Paper

Pituitary Hormone Suppressant
Amino Acid [EPC]
Recombinant Gonadorelin
Analog
Dose-Response Relationship, Drug

Related Papers

Paper Details
References
  • References10
  • Citations2
1

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