Inhibitory activity of Brazilian green propolis components and their derivatives on the release of cys-leukotrienes

Bioorganic & Medicinal Chemistry
Hiroko TaniShunya Takahashi

Abstract

The effects of Brazilian green propolis ethanol extract on Cry j1-induced cys-leukotrienes and histamine release from peripheral leukocytes of patients with allergic rhinitis were investigated. One of the key mechanisms for the anti-allergic properties of the extract was revealed to be the suppression of cys-LTs release. Furthermore, a series of propolis components and their phenethyl esters were synthesized and evaluated as inhibitors of cys-LTs release. Artepillin C, baccharin, and kaempferide were the major active components of the ethanol extract. The inhibitory activity of artepillin C phenethyl ester was comparable to that of existing LT synthesis inhibitors.

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Citations

Jun 19, 2012·Clinical Reviews in Allergy & Immunology·Godfrey Chi-Fung ChanDaniel Man-Yuen Sze
Jan 6, 2015·Chemico-biological Interactions·Tianzhu ZangTrevor M Penning
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Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Batoryna OlgierdMorawiec Emilia
Dec 7, 2020·Allergology International : Official Journal of the Japanese Society of Allergology·Jun-Ichi KashiwakuraTadashi Matsuda
Jun 18, 2021·Food Science & Nutrition·Norihisa MikamiTomoki Ikuta
Feb 8, 2020·Journal of Natural Products·Alberto G CostaFernanda R Garcez

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