PMID: 7517501Jul 1, 1994Paper

Inhibitory activity of cigarette-smoke condensate on the mutagenicity of heterocyclic amines

Mutation Research
C K LeeD J Doolittle

Abstract

Cigarette-smoke condensate (CSC) is a complex mixture containing over 3800 identified chemicals including nicotine, water, mutagens, antimutagens, cytotoxins and inert chemicals. Although CSC is mutagenic in the Ames test, its effect on the activity of other mutagens has not been characterized. Using the Ames Salmonella bacterial mutagenesis assay, we found CSC exerts a significant inhibitory effect on mutagens requiring bioactivation. Those studied included heterocyclic amines (Glu-P-1, Glu-P-2, IQ, MeIQ, Trp-P-1 and Trp-P-2), benzo[a]pyrene (B[a]P) and aflatoxin B1. However, CSC had no effect on the activity of direct-acting mutagens (2-nitrofluorene, sodium azide, 4-nitro-1,2-phenylenediamine, 4-nitroquinoline N-oxide and methyl methanesulfonate). With indirect-acting mutagens, the reduced number of revertants observed in the presence of CSC was not attributable to cytotoxicity. CSC exhibited a potent inhibitory effect on the cytochrome P-450 dependent monooxygenases, ethoxyresorufin O-deethylase and B[a]P hydroxylase. This suggests inhibition of the cytochrome P-450 isozymes as one possible mechanism for the antimutagenicity of CSC. Fractionation studies of CSC revealed that the neutral, weakly acidic (phenolic) and basic f...Continue Reading

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Citations

Aug 15, 2000·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·C J Smith, C Hansch
Aug 2, 2011·Carcinogenesis·Barbara E WrightDennis K Reschke
Dec 5, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Michael D JohnsonPeter G Shields
Apr 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·B E WrightJ M Reimers
Nov 26, 1996·Proceedings of the National Academy of Sciences of the United States of America·A Beletskii, A S Bhagwat
Mar 4, 2015·Proceedings of the National Academy of Sciences of the United States of America·Kelley Harris
Sep 16, 2006·The Journal of Biological Chemistry·Ailing ZhangLeroy F Liu

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