PMID: 8608192Oct 1, 1995Paper

Inhibitory and disruptive effects of some antirheumatics on antigen-antibody complexes

European Journal of Clinical Chemistry and Clinical Biochemistry : Journal of the Forum of European Clinical Chemistry Societies
E KalleeR Wahl

Abstract

Purified antibodies to human serum albumin or to human gamma-globulin were used to study the direct influence of some antirheumatic drugs on the formation and disruption of immunoprecipitates. 125I-labelled human serum albumin and 125I-labelled human IgG served as indicators. The effects of the following drugs were described: diclofenac, monophenylbutazone, diphenylbutazone, ibuprofen, and metamizol. At approximately therapeutic concentrations, the antirheumatics inhibited the formation of complexes of homologous antibodies with human serum albumin and, surprisingly, with human IgG. When the antigens were precipitated with antibodies, subsequent addition of the antirheumatics to the preformed immunoprecipitates caused disruption of [125I]human serum albumin-anti-human serum albumin precipitates but practically no disruption of human [125I]IgG-anti-human IgG precipitates. These new findings may be of relevance for clinical diagnosis and therapy as well as for research in immunochemistry. It is conceivable that, in patients, antirheumatic or other drugs might interfere with immunological determinations of clinico-chemical quantities. Interference of drugs with antigen-antibody reactions might also help to explain some beneficial ...Continue Reading

References

Oct 17, 1977·European Journal of Biochemistry·R WahlE Kallee
Mar 1, 1990·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·E Kallee, R Wahl
Nov 1, 1993·Neurology·K Sathian
Jan 1, 1959·Clinica Chimica Acta; International Journal of Clinical Chemistry·F LOHSS, E KALLEE

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Citations

Nov 10, 2015·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Martina BaliovaFrantisek Jursky
Jan 3, 2001·Medical Hypotheses·L Saso, B Silvestrini

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