PMID: 2499662Jan 1, 1989Paper

Inhibitory and excitatory amino acids in cerebrospinal fluid of chronic epileptic patients

Journal of Neural Transmission
A PitkänenP J Riekkinen

Abstract

We studied the levels of excitatory and inhibitory amino acids in the cerebrospinal fluid (CSF) of 28 epileptic patients (24 with partial type seizures, 4 with primary generalized seizures) and 12 controls. The levels of aspartate were 63% (p less than 0.01), glutamine 129% (p less than 0.001), and homocarnosine 127% (p less than 0.005) that of controls. The concentrations of glutamate, asparagine, total GABA, free GABA, taurine, and glycine did not differ between epileptic patients and controls. Patients with partial epilepsy had a pattern of amino acids in CSF similar to that in patients with primary generalized seizures. In the present study we did not observe increased excitation or decreased inhibition in the seizure-active brains of epileptics, as far as the CSF levels of amino acids reflect their levels in the brain.

References

Jan 1, 1986·Acta Neurologica Scandinavica. Supplementum·B Pedersen, M Dam
Jan 1, 1987·Journal of Neural Transmission·A PitkänenM Lehtinen
May 1, 1985·Archives of Neurology·M KnightM H Fogelson
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Citations

Jul 1, 1995·Brain Research. Brain Research Reviews·M Glass, M Dragunow
May 1, 1991·Epilepsy Research·A HambergerC Nordborg
Apr 21, 1999·Epilepsy Research·C D FerrieR O Robinson
May 25, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·C T PengC H Tsai
Dec 7, 2002·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Ognen A C Petroff

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