Inhibitory and stimulatory effects of Pseudomonas aeruginosa pyocyanine on human T and B lymphocytes and human monocytes.

Infection and Immunity
A J UlmerH D Flad

Abstract

Pyocyanine, a pigment produced by Pseudomonas aeruginosa, has dual dose-dependent stimulatory as well as inhibitory effects on immune responses in vitro as measured by DNA synthesis of human T and B lymphocytes, interleukin-2 (IL-2) production by human T lymphocytes, immunoglobulin production by human B lymphocytes, and monokine production by human monocytes. In general, stimulatory activity was found at low concentrations of pyocyanine, whereas high concentrations of the pigment resulted in an inhibition of responses. At a pyocyanine concentration of 0.1 micrograms/ml or less the proliferation of T and B lymphocytes was enhanced, but at 0.5 micrograms/ml it was suppressed. IL-2 production by T lymphocytes was enhanced at concentrations up to 0.5 micrograms/ml but totally inhibited at 1.0 micrograms/ml. The differentiation of B lymphocytes to become immunoglobulin-producing cells was also enhanced in the presence of low doses of pyocyanine, whereas secretion of immunoglobulin by B lymphocytes was suppressed at all concentrations of pyocyanine. In contrast to the dual effects of pyocyanine on lymphocyte response, lipopolysaccharide-induced IL-1 and tumor necrosis factor release by monocytes was markedly enhanced by low as well a...Continue Reading

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Citations

Nov 29, 2001·Proceedings of the National Academy of Sciences of the United States of America·H CaoL G Rahme
Nov 4, 2008·Immunologic Research·Balázs Rada, Thomas L Leto
Dec 2, 2009·Infection and Immunity·Tao Dong, Herb E Schellhorn
Jul 23, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·Yunxia Q O'MalleyBradley E Britigan
Sep 24, 2004·Infection and Immunity·David L EricksonDouglas G Storey
May 2, 2019·Microbiology and Immunology·Gopi Krishnan Gopala KrishnanMaheswaran Mani
Jan 1, 1997·Clinical Microbiology Reviews·R A Miller, B E Britigan
May 1, 1995·Infection and Immunity·C H ModyD E Woods
Oct 3, 2003·Microbial Pathogenesis·Elisabeth SonnleitnerUdo Bläsi
Oct 17, 2019·ACS Infectious Diseases·Zhijuan Hu, Wenjun Zhang

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