Inhibitory autocrine factors produced by the mesenchyme-derived hair follicle dermal papilla may be a key to male pattern baldness

The British Journal of Dermatology
K Hamada, V A Randall

Abstract

Androgenetic alopecia, or male pattern baldness, is a common, progressive disorder where large, terminal scalp hairs are gradually replaced by smaller hairs in precise patterns until only tiny vellus hairs remain. This balding can cause a marked reduction in the quality of life. Although these changes are driven by androgens, most molecular mechanisms are unknown, limiting available treatments. The mesenchyme-derived dermal papilla at the base of the mainly epithelial hair follicle controls the type of hair produced and is probably the site through which androgens act on follicle cells by altering the regulatory paracrine factors produced by dermal papilla cells. During changes in hair size the relationship between the hair and dermal papilla size remains constant, with alterations in both dermal papilla volume and cell number. This suggests that alterations within the dermal papilla itself play a key role in altering hair size in response to androgens. Cultured dermal papilla cells offer a useful model system to investigate this as they promote new hair growth in vivo, retain characteristics in vitro which reflect their parent follicle's response to androgens in vivo and secrete mitogenic factors for dermal papilla cells and k...Continue Reading

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Citations

Jul 29, 2006·Lasers in Medical Science·V A RandallL Chamberlain James
Dec 19, 2013·Indian Dermatology Online Journal·Lata SharmaAruna Agrawal
Dec 22, 2009·Journal of Dermatological Science·Chao-Chun Yang, George Cotsarelis
Jul 28, 2007·The Journal of Investigative Dermatology·Mi Hee KwackJung Chul Kim
Nov 9, 2007·The Journal of Investigative Dermatology·Adiam W BahtaMike P Philpott
Mar 24, 2007·Seminars in Cell & Developmental Biology·Valerie Anne Randall
Nov 6, 2012·Cell Biology International Reports·Minjuan WuHouqi Liu
Nov 15, 2014·Journal of Medicinal Food·Gyeong-Hun ParkDong Hun Lee
Nov 19, 2008·Child Neuropsychology : a Journal on Normal and Abnormal Development in Childhood and Adolescence·Kate D RandallKimberly A Kerns
Jul 12, 2017·Expert Opinion on Investigational Drugs·Hongwei GuoKevin John McElwee
Oct 11, 2008·Dermatologic Therapy·Valerie Anne Randall

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