Inhibitory control of site-specific synaptic plasticity in a model CA1 pyramidal neuron

Bio Systems
A Saudargiene, Bruce P Graham

Abstract

A computational model of a biochemical network underlying synaptic plasticity is combined with simulated on-going electrical activity in a model of a hippocampal pyramidal neuron to study the impact of synapse location and inhibition on synaptic plasticity. The simulated pyramidal neuron is activated by the realistic stimulation protocol of causal and anticausal spike pairings of presynaptic and postsynaptic action potentials in the presence and absence of spatially targeted inhibition provided by basket, bistratified and oriens-lacunosum moleculare (OLM) interneurons. The resulting Spike-timing-dependent plasticity (STDP) curves depend strongly on the number of pairing repetitions, the synapse location and the timing and strength of inhibition.

References

Aug 1, 1982·Electroencephalography and Clinical Neurophysiology·L W LeungW J Wadman
Jun 27, 1997·Science·J LismanR Malinow
Aug 15, 1997·Neural Computation·M L Hines, N T Carnevale
Jan 15, 1999·Science·U S Bhalla, R Iyengar
Feb 8, 2002·Neuron·Bernardo L SabatiniKarel Svoboda
May 8, 2002·Nature Reviews. Neuroscience·J LismanH Cline
Jul 13, 2002·Proceedings of the National Academy of Sciences of the United States of America·Henry D I AbarbanelM I Rabinovich
Jul 19, 2002·Nature·Nace L GoldingNelson Spruston
Jul 24, 2002·Proceedings of the National Academy of Sciences of the United States of America·Harel Z ShouvalLeon N Cooper
Feb 21, 2003·Nature·Thomas KlausbergerPeter Somogyi
Apr 3, 2003·Neuron·Panayiota PoiraziBartlett W Mel
Jul 10, 2003·Current Opinion in Neurobiology·Michael Häusser, Bartlett Mel
Mar 10, 2004·Neural Computation·Ausra SaudargieneFlorentin Wörgötter
Jul 9, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mariana Vargas-Caballero, Hugh P C Robinson
Sep 29, 2004·Neuron·Robert C Malenka, Mark F Bear
Jun 29, 2005·Proceedings of the National Academy of Sciences of the United States of America·Daniel H O'ConnorSamuel S-H Wang
May 12, 2006·International Journal of Neural Systems·Mathilde BadoualAlain Destexhe
Jun 16, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Gayle M Wittenberg, Samuel S-H Wang
Sep 22, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jean-Pascal Pfister, Wulfram Gerstner
Oct 13, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Johannes J LetzkusGreg J Stuart
Dec 7, 2007·PLoS Computational Biology·Michael Graupner, Nicolas Brunel
Mar 28, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hidetoshi UrakuboShinya Kuroda
Apr 9, 2008·Physiological Reviews·P Jesper SjöströmMichael Häusser
Dec 5, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hyun Jae Pi, John E Lisman
Mar 20, 2010·Nature Reviews. Neuroscience·Jeanette Hellgren Kotaleski, Kim T Blackwell
Apr 2, 2010·Journal of Neurophysiology·Francesco Savelli, James J Knierim
Aug 21, 2010·Frontiers in Computational Neuroscience·Harel Z ShouvalGayle M Wittenberg
Sep 14, 2010·Neural Networks : the Official Journal of the International Neural Network Society·Vassilis Cutsuridis
Oct 16, 2010·Frontiers in Computational Neuroscience·Michael Graupner, Nicolas Brunel
Dec 2, 2010·Journal of Computational Neuroscience·Kristofor D Carlson, Nicholas Giordano
Dec 29, 2010·Frontiers in Computational Neuroscience·Tiina ManninenMarja-Leena Linne
Jan 1, 2010·Frontiers in Synaptic Neuroscience·Katherine A Buchanan, Jack R Mellor
Jan 1, 2010·Frontiers in Synaptic Neuroscience·Robert C FroemkeGreg J Stuart
Apr 12, 2011·Neural Networks : the Official Journal of the International Neural Network Society·Bernd PorrFlorentin Wörgötter
Feb 24, 2012·Proceedings of the National Academy of Sciences of the United States of America·Michael Graupner, Nicolas Brunel
May 23, 2012·Journal of Computational Neuroscience·Daniel Bush, Yaochu Jin
Jan 1, 2012·Frontiers in Neural Circuits·Lital Bar-IlanIdan Segev

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Citations

Mar 24, 2016·PLoS Computational Biology·Katharina A WilmesSusanne Schreiber
Jul 19, 2018·Frontiers in Computational Neuroscience·Alexandre FoncelleLaurent Venance
Nov 24, 2020·Frontiers in Synaptic Neuroscience·Claire Meissner-BernardWulfram Gerstner

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