Inhibitory control of somatodendritic interactions underlying action potentials in neocortical pyramidal neurons in vivo: an intracellular and computational study

Neuroscience
D ParéAlain Destexhe

Abstract

The effect of synaptic inputs on somatodendritic interactions during action potentials was investigated, in the cat, using in vivo intracellular recording and computational models of neocortical pyramidal cells. An array of 10 microelectrodes, each ending at a different cortical depth, was used to preferentially evoke synaptic inputs to different somatodendritic regions. Relative to action potentials evoked by current injection, spikes elicited by cortical microstimuli were reduced in amplitude and duration, with stimuli delivered at proximal (somatic) and distal (dendritic) levels evoking the largest and smallest decrements, respectively. When the inhibitory postsynaptic potential reversal was shifted to around -50 mV by recording with KCl pipettes, synaptically-evoked spikes were significantly less reduced than with potassium acetate or cesium acetate pipettes, suggesting that spike decrements are not only due to a shunt, but also to voltage-dependent effects. Computational models of neocortical pyramidal cells were built based on available data on the distribution of active currents and synaptic inputs in the soma and dendrites. The distribution of synapses activated by extracellular stimulation was estimated by matching the...Continue Reading

References

Feb 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·R K WongA I Basbaum
Jul 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·R Llinás, R Hess
Feb 1, 1990·Trends in Neurosciences·J A BlackS G Waxman
Jan 1, 1991·The Journal of Physiology·R J DouglasD Whitteridge
Nov 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·D A Wollner, W A Catterall
Jan 1, 1987·Annual Review of Biophysics and Biophysical Chemistry·G Yellen
Jun 1, 1988·The Journal of Cell Biology·K J AngelidesE Elson
Apr 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J R HuguenardD A Prince
Jun 1, 1986·The Journal of Physiology·D A McCormick, D A Prince
Jan 1, 1987·Progress in Neurobiology·M L Mayer, G L Westbrook
Mar 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·B H Gähwiler, D A Brown
Oct 1, 1985·Journal of Neurophysiology·D A McCormickD A Prince
Jan 29, 1970·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·E G Jones, T P Powell
Jul 1, 1971·Journal of Neurophysiology·R Llinas, C Nicholson
Apr 1, 1970·The American Journal of Anatomy·A Peters, I R Kaiserman-Abramof
Dec 1, 1968·The Journal of Cell Biology·A PetersI R Kaiserman-Abramof
Dec 1, 1982·Journal of Neurophysiology·B W ConnorsD A Prince
Sep 1, 1984·The Journal of Physiology·D V Madison, R A Nicoll
Jan 1, 1981·Experimental Brain Research·M Deschênes
May 24, 1994·Proceedings of the National Academy of Sciences of the United States of America·H Markram, B Sakmann
Oct 1, 1993·Biophysical Journal·A DestexheT J Sejnowski
Jul 1, 1993·Neuron·W RegehrC Armstrong
Jan 7, 1993·Nature·T V Bliss, G L Collingridge
Sep 3, 1996·Proceedings of the National Academy of Sciences of the United States of America·G BuzsákiA Bragin

❮ Previous
Next ❯

Citations

Jul 10, 2007·Biological cybernetics·William S AndersonPiotr J Franaszczuk
Feb 10, 2004·Mathematical Biosciences·Nicolangelo IannellaShigeru Tanaka
Sep 21, 2007·Stereotactic and Functional Neurosurgery·J E ArleJ L Shils
Jan 21, 2014·Journal of Computational Neuroscience·Victor J BarrancaDavid Cai
Apr 4, 2009·Journal of Computational Neuroscience·Danielle Morel, William Levy
Feb 3, 2009·Epilepsy Research·William S AndersonPiotr J Franaszczuk
Apr 22, 2004·The Journal of Comparative Neurology·Ruggero ScorcioniGiorgio A Ascoli
Nov 29, 2011·Journal of Neuroscience Methods·Hinnerk Feldwisch-DrentrupMark C W van Rossum
Aug 2, 2007·PloS One·Ramon Reig, Maria V Sanchez-Vives
Jan 24, 2007·PLoS Computational Biology·Wolfgang MaassEduardo D Sontag
Jan 17, 2009·PLoS Computational Biology·Lucy J Colwell, Michael P Brenner
May 17, 2011·PLoS Computational Biology·Jonathan Platkiewicz, Romain Brette
Sep 15, 2009·PLoS Computational Biology·Balázs UjfalussyPéter Erdi
Jul 19, 2008·PLoS Computational Biology·Sungho HongAdrienne L Fairhall
Nov 22, 2008·PloS One·Peyman Khorsand, Frances Chance
Oct 15, 2011·PLoS Computational Biology·Robert B Levy, Alex D Reyes
Feb 27, 2015·PLoS Computational Biology·Renaud JolivetPierre J Magistretti
Jan 20, 2010·PLoS Biology·Tara C ThiagarajanDietmar Plenz
Jun 18, 2015·PLoS Computational Biology·Christian PozzoriniWulfram Gerstner
Dec 2, 2005·Journal of Theoretical Biology·Pierre A Fortier, Maimouna Bagna
Jun 11, 2011·Neural Networks : the Official Journal of the International Neural Network Society·Dominic Standage, Martin Paré
Dec 7, 2007·Journal of Physiology, Paris·Jonathan Touboul, Olivier Faugeras
Jun 9, 2009·Journal of Physiology, Paris·Martin PospischilAlain Destexhe

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.