Inhibitory control of synaptic and behavioral plasticity by octopaminergic signaling.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Alex C Koon, Vivian Budnik

Abstract

Adrenergic receptors and their ligands are important regulators of synaptic plasticity and metaplasticity, but the exact mechanisms underlying their action are still poorly understood. Octopamine, the invertebrate homolog of mammalian adrenaline or noradrenaline, plays important roles in modulating behavior and synaptic functions. We previously uncovered an octopaminergic positive-feedback mechanism to regulate structural synaptic plasticity during development and in response to starvation. Under this mechanism, activation of Octß2R autoreceptors by octopamine at octopaminergic neurons initiated a cAMP-dependent cascade that stimulated the development of new synaptic boutons at the Drosophila larval neuromuscular junction (NMJ). However, the regulatory mechanisms that served to brake such positive feedback were not known. Here, we report the presence of an alternative octopamine autoreceptor, Octß1R, with antagonistic functions on synaptic growth. Mutations in octß1r result in the overgrowth of both glutamatergic and octopaminergic NMJs, suggesting that Octß1R is a negative regulator of synaptic expansion. As Octß2R, Octß1R functioned in a cell-autonomous manner at presynaptic motorneurons. However, unlike Octß2R, which activat...Continue Reading

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Citations

Jan 8, 2015·Frontiers in Endocrinology·Dick R Nässel, Michael J Williams
Nov 23, 2018·G3 : Genes - Genomes - Genetics·Balint Z KacsohGiovanni Bosco
May 17, 2019·Genes, Brain, and Behavior·Patricka A Williams-SimonElizabeth G King
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Dec 12, 2018·G3 : Genes - Genomes - Genetics·Juan J Pérez-Moreno, Cahir J O'Kane

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