Inhibitory deterioration may contribute to hallucinations in Alzheimer's disease

Cognitive Neuropsychiatry
Mohamad El HajStéphane Raffard

Abstract

Although delusions and hallucinations are relatively common symptoms in individuals with Alzheimer's disease (AD), very little is known regarding underlying mechanisms. We examined whether these manifestations could be underpinned by psychological distress and executive impairments. Thirty-one participants with probable mild AD and 33 healthy older adults were administered a neuropsychological and clinical battery assessing delusions, hallucinations, anxiety, depression, episodic memory and executive functions (shifting, updating and inhibition). Prevalence of delusions and hallucinations were significantly higher in AD participants compared to control participants. Further, hallucinations in AD participants were significantly correlated with poor inhibition, with the latter uniquely predicting the former, as compared to other variables. In addition, hallucinations in AD participants were associated with depression, a relationship that was further mediated by inhibition. Hallucinations in individuals with AD seem to be related to difficulties suppressing irrelevant thoughts, resulting in these irrelevant thoughts becoming confused with ongoing reality.

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Citations

Jan 8, 2016·Cognitive Neuropsychiatry·Mohamad El HajPascal Antoine
Dec 25, 2015·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Mohamad El Haj
Feb 27, 2018·Cognitive Neuropsychiatry·Mohamad El HajFranck Larøi
Mar 17, 2019·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·Joshua T FullerUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Oct 13, 2020·Cognitive Neuropsychiatry·Mohamad El HajFrank Larøi
Sep 29, 2020·Acta Neuropsychiatrica·Mohamad El Haj, Frank Larøi
Oct 6, 2021·Memory·Mohamad El Haj, Frédérique Robin

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Software Mentioned

Statistical Package for the Social Sciences ( SPSS Statistics
SPSS

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