Inhibitory effect of (-)-epigallocatechin 3-gallate, a polyphenol of green tea, on neutrophil chemotaxis in vitro and in vivo

Journal of Agricultural and Food Chemistry
Katsuhiko TakanoHideo Nakagawa

Abstract

The effect of (-)-epigallocatechin 3-gallate (EGCG), a major polyphenol of green tea, on neutrophil migration has been studied using multiwell-type Boyden chambers in vitro and a fluorescein isothiocyanate-labeled ovalbumin (FITC-OVA)-induced rat allergic inflammation model in vivo. EGCG inhibited rat neutrophil chemotaxis toward cytokine-induced neutrophil chemoattractant-1 (CINC-1) in a concentration-dependent manner. In addition, CINC-1-induced neutrophil chemotaxis was suppressed by the pretreatment of rat neutrophils with EGCG at the concentration over 15 microg/mL. EGCG caused concentration-dependent suppression of the transient increase in CINC-1-induced intracellular free calcium level in both rat neutrophils and rat CXC chemokine receptor 2 (CXCR2)-transfected HEK 293 cells. EGCG inhibited CINC-1 production by IL-1beta-stimulated rat fibroblasts (NRK-49F cells) and lipopolysaccharide-stimulated rat macrophages at the concentration over 50 microg/mL, a comparatively high concentration. Oral administration of EGCG (1.0 mg or 1.5 mg/rat) at 1 h before the challenge with FITC-OVA suppressed neutrophil infiltration into the air pouch (inflammatory site) in the air-pouch type FITC-OVA-induced allergic inflammation in rats. C...Continue Reading

References

May 1, 1995·Biological & Pharmaceutical Bulletin·Y OhmoriH Konishi
Aug 1, 1995·Bioscience, Biotechnology, and Biochemistry·T Unno, T Takeo
Mar 3, 1998·International Archives of Allergy and Immunology·H NakagawaY Sunada
Apr 14, 1999·Nature·Y Cao, R Cao
Aug 2, 2001·Biochemical and Biophysical Research Communications·S HayakawaM Isemura
Nov 21, 2001·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·K Takano, H Nakagawa
Apr 12, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Massimo DonàSpiridione Garbisa

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Citations

Jan 11, 2012·Clinical and Experimental Pharmacology & Physiology·Judith C W Mak
Jul 17, 2008·Biological Chemistry·Munekazu YamakuchiCharles J Lowenstein
Feb 22, 2012·ISRN Cardiology·Yaling YangBrian Tomlinson
Mar 30, 2013·Canadian Journal of Physiology and Pharmacology·Sandhya KhuranaT C Tai
May 9, 2015·Seminars in Cancer Biology·Abbas K SamadiXujuan Yang
Apr 12, 2011·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Apranta Deka, Joseph A Vita
Feb 11, 2009·The Journal of Allergy and Clinical Immunology·Christina L NanceWilliam T Shearer
Mar 30, 2007·Microbial Pathogenesis·Oksun ChoiMasatoshi Noda
Jan 27, 2007·Photodermatology, Photoimmunology & Photomedicine·Nabiha YusufCraig A Elmets
Mar 28, 2006·Biochemical Pharmacology·Bharat B Aggarwal, Shishir Shishodia
Mar 30, 2016·The Journal of Surgical Research·Bernhard KasperStefan Dhein
Aug 22, 2015·Immunologic Research·Wei LiHaichao Wang
Oct 20, 2011·Journal of Ethnopharmacology·Lucimara Q MoreiraAlexandre Giusti-Paiva
Jan 1, 2017·Physiological Reports·Adam R JajtnerJeffrey R Stout
Jul 17, 2015·The American Journal of Clinical Nutrition·Mark D FarrarLesley E Rhodes
Feb 14, 2017·Journal of Translational Internal Medicine·Hui Bao, Ai Peng
Jun 30, 2018·Medicine and Science in Sports and Exercise·Adam R JajtnerJay R Hoffman
Jan 13, 2006·Molecular Nutrition & Food Research·Verena StanglKarl Stangl
Apr 13, 2007·Macromolecular Bioscience·Hiroshi Uyama
Aug 11, 2015·Journal of Complementary & Integrative Medicine·Gordon M LoweKhalid Rahman
Jul 30, 2020·Polymers·Subhalakshmi NagarajanFerdinando Bruno
Jan 31, 2019·Frontiers in Immunology·Dayong WuSimin Nikbin Meydani
Feb 11, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shulin QinTodd A Reinhart
Feb 14, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Camila R FerrazWaldiceu A Verri

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