Inhibitory effect of 3-caffeoyl-4-dicaffeoylquinic acid from Salicornia herbacea against phorbol ester-induced cyclooxygenase-2 expression in macrophages

Chemico-biological Interactions
Eun Hee HanHye Gwang Jeong

Abstract

Salicornia herbacea (S. herbacea), an annual herb that grows in the salt marshes of the Korean peninsula, has been used as a folk medicine to treat a variety of diseases such as constipation, obesity, diabetes, and cancer. However, the effect of S. herbacea on inflammation is unclear. In the present study, we investigated the effects of a novel chlorogenic acid, 3-caffeoyl-4-dicaffeoylquinic acid (CDCQ), isolated from S. herbacea, on cyclooxygenase-2 (COX-2) expression in murine macrophage RAW 264.7 cells. Phorbol 12-myristate 13-acetate (PMA) induces COX-2 expression and production of prostaglandin E(2) (PGE(2)). PMA-induced COX-2 protein, gene expression and PGE(2) production were significantly inhibited by CDCQ in a dose-dependent manner. Transfection of hCOX-2, as well as of deletion and mutation promoter constructs, revealed that the CCAAT/enhancer-binding protein (C/EBP) and activator protein-1 (AP-1) predominantly contributed to the effects of CDCQ. In addition, electrophoretic mobility shift assays and transfection results showed that CDCQ directly inhibited PMA-induced C/EBP and AP-1 transcription and binding activity. CDCQ also remarkably reduced PMA-induced C/EBPbeta and c-jun protein expression. Furthermore, CDCQ si...Continue Reading

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Citations

Mar 19, 2011·Journal of Ethnopharmacology·C B HebedaS H P Farsky
Feb 23, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Hyung Gyun KimHye Gwang Jeong
Jan 21, 2015·Journal of Photochemistry and Photobiology. B, Biology·Gwladys SurgetNathalie Poupart
May 12, 2018·Inflammopharmacology·Janka Schulte-MichelsSebastian Franken
Oct 30, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yu-Chan KoDong-Sun Lee
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sojeong KimSang-Jip Nam

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