Inhibitory effect of a traditional Chinese medicine, Juzen-taiho-to, on progressive growth of weakly malignant clone cells derived from murine fibrosarcoma

Japanese Journal of Cancer Research : Gann
Y OhnishiI Saiki

Abstract

We have investigated the inhibitory effect of oral administration of Juzen-taiho-to, a Kampo (Chinese herbal) medicine, on progressive growth of a mouse fibrosarcoma. Spontaneously regressive QR-32 tumor cells were able to grow progressively in vivo when coimplanted s.c. with a foreign body, gelatin sponge, whereas QR-32 cells alone gradually grew for over 15 days after inoculation and thereafter regressed for up to 25 days. Oral administration of Juzen-taiho-to (40 mg/day/mouse) for 7 days after inoculation of QR-32 cells with gelatin sponge resulted in significant inhibition of tumor growth and prolongation of the survival of the tumor-bearing mice. This growth-inhibitory effect of Juzen-taiho-to observed on day 25 was dose-dependent over the dose range from 4 to 40 mg/day. Treatment with Juzen-taiho-to for 7 days before tumor inoculation with gelatin sponge also significantly suppressed tumor growth examined on day 25, as did the administration of bismuth subnitrate, which is well known to induce metallothionein, an antioxidant. On the other hand, inoculation of progressed tumor cells (QRsP) resulted in growth without gelatin sponge, leading to death in syngeneic mice. Administration of Juzen-taiho-to for 7 days after inocul...Continue Reading

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Citations

Oct 12, 2000·Journal of Ethnopharmacology·A T BorchersM E Gershwin
Jul 20, 2002·Journal of Ethnopharmacology·Guang-Bi JinJong-Chol Cyong
Dec 19, 2006·Evidence-based Complementary and Alternative Medicine : ECAM·H KiyoharaH Yamada
Jun 17, 2005·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·T KogureK Terasawa
Jun 26, 2014·Mediators of Inflammation·Youn Kyung ChoiSeong-Gyu Ko
Apr 20, 2017·International Journal of Molecular Sciences·Yusuke KandaFutoshi Okada
Sep 8, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tae Hwan KimBeom Soo Shin
Mar 27, 2004·Pediatrics International : Official Journal of the Japan Pediatric Society·Toshiki OhyaTakehisa Iwai

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