Inhibitory effect of Agrimonia pilosa Ledeb. on inflammation by suppression of iNOS and ROS production

Immunological Investigations
Chang Hwa JungSeong-Gyu Ko

Abstract

Herbal medicines including Agrimonia pilosa Ledeb. (APL) have been traditionally used to treat inflammations including allergic disease as valuable medicinal properties. To investigate the attenuating ability of APL on inflammation, the NO release and ROS production, which play a key role in inflammatory and immune responses, was first tested using in vitro assay. The 80% ethanol extract of APL showed a significant activity to inhibit NO release and ROS production. In additional extracts from 80% ethanol extract of APL, n-butanol (BuOH) extract displayed the most potent anti-inflammatory effects based on in vitro assay. The extract also significantly reduced nitric oxide in lipopolysaccharide-activated RAW 264.7 macrophage cells (p < 0.05), and suppressed the nitric oxide synthase (iNOS) expression, whereas the extract showed no inhibitory effect on cyclooxygenase-2 (COX-2) expression, suggesting that the BuOH extract of APL could reduce the NO production through suppression of iNOS, but not COX-2. The BuOH extract also showed a significant effect in a carrageenan-induced rat paw edema in vivo model, consistent with our in vitro results. Our findings suggest that the BuOH extract of APL shows a potential anti-inflammatory activ...Continue Reading

References

Feb 1, 1987·Japanese Journal of Pharmacology·K MiyamotoR Koshiura
Feb 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·W F PetroneJ M McCord
Apr 1, 1993·Free Radical Biology & Medicine·S J Klebanoff
Aug 27, 1998·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·S J CutlerS H Pollock
Mar 30, 2001·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·K T LimD D Kitts
Nov 21, 2001·Journal of Agricultural and Food Chemistry·J A VinsonP Bose
May 10, 2002·The Journal of Pharmacy and Pharmacology·Paul Bremner, Michael Heinrich
Oct 16, 2002·Glia·Uwe-Karsten Hanisch
Oct 7, 2003·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Alejandra Ester RotelliLilian Eugenia Pelzer
Oct 30, 2003·Journal of Agricultural and Food Chemistry·Joseph M AwikaLuis Cisneros-Zevallos
Feb 19, 2004·Journal of Agricultural and Food Chemistry·Kizhiyedathu Polachira SujaChami Arumughan
Oct 12, 2004·Archives of Pharmacal Research·Eun-Jeon ParkYoun-Chul Kim
Jun 9, 2005·Seminars in Arthritis and Rheumatism·Arathi R Setty, Leonard H Sigal
Aug 22, 2006·Biochemical Pharmacology·Irfan RahmanPaul A Kirkham
Oct 29, 2008·Evidence-based Complementary and Alternative Medicine : ECAM·Hui LiaoDavid N Leach

❮ Previous
Next ❯

Citations

Dec 25, 2012·BMC Complementary and Alternative Medicine·Young Min LeeHaeng Ran Kim
Nov 22, 2013·Oxidative Medicine and Cellular Longevity·Min-Ji BakWoo-Sik Jeong
Sep 10, 2014·BMC Veterinary Research·Tobias GräberGabriele I Stangl
Mar 28, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Ji Young ChaWon G An
Jun 13, 2012·Biological & Pharmaceutical Bulletin·Eun-Kyung AhnJoa Sub Oh
Sep 29, 2011·Journal of Ethnopharmacology·Kyoung Jin NhoHo Kyoung Kim
Jun 21, 2016·Biochemical and Biophysical Research Communications·Shifeng WangYanjiang Qiao
May 9, 2012·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Soo-Hyun ParkHong-Won Suh
May 12, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Telmo N SantosM Teresa Batista
Jul 4, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Choon Young KimJung-Sook Seo
Dec 15, 2020·The American Journal of Chinese Medicine·Da-Sol KimHye-Ock Jang
Mar 2, 2021·Physiological Research·Z PaluchE Kmoníčková
Apr 20, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Chul Won LeeWon G An

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here