PMID: 9422083Jan 9, 1998Paper

Inhibitory effect of amiloride on the urokinase plasminogen activators in prostatic cancer

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
P RayS Nasruddin

Abstract

The diuretic drug amiloride (AMLD), which competitively inhibits the catalytic activity of urokinase plasminogen activators (UPA), was used to study its effects on the proteolytic enzymes implicated in the invasiveness and metastases in a prostatic tumor model carrying two different sublines of adenocarcinoma of the prostate. Our data showed that UPA activity was significantly higher, both in the cytosol and pellet of R3327-AT3, a fast-growing highly metastatic and androgen-insensitive tumor, as compared to the G3327-G subline, a slow-growing nonmetastatic tumor of the prostate. The UPA activity in AT3 tumor dropped when the rats were treated with AMLD for 3 weeks. The UPA activity in the sera and tumor effusions from rats with AT3 tumor was significantly higher as compared to those with G subline tumor. The number of pulmonary metastatic foci was the same in untreated rats as compared to those treated with AMLD. The lymph node inspection after 3 weeks revealed no secondary tumor in the AMLD-treated group. The role of UPA in the metastases of prostate cancer is discussed.

Citations

May 7, 2002·Cell Biology International·Kimberly D DyerMark C Alliegro
Nov 4, 2000·Expert Opinion on Investigational Drugs·S D DunbarL R Zacharski
Jun 24, 2016·American Journal of Physiology. Renal Physiology·Leopoldo RaijKirk N Campbell
Oct 21, 2004·Cancer·David G BostwickBarry Timms
May 6, 2011·International Journal of Cancer. Journal International Du Cancer·Hayden MatthewsMichael J Kelso
Feb 26, 2021·Breast Cancer Research and Treatment·Adam W WareFiona J McDonald

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