Inhibitory effect of antidepressant drugs on contact hypersensitivity reaction is connected with their suppressive effect on NKT and CD8(+) T cells but not on TCR delta T cells

International Immunopharmacology
Katarzyna CurzytekWładysław Lasoń

Abstract

Contact hypersensitivity (CHS) reaction induced by a topical application of hapten is a cell-mediated antigen-specific type of skin inflammation mediated by interaction of several subtypes of T cell subpopulations. Recently, it has been shown that antidepressant drugs inhibit CHS reaction, although the mechanism of this effect remains unknown. The aim of the present study was to investigate the effect of 2-week desipramine or fluoxetine administration on the CHS reaction induced by picryl chloride (PCL) application in B10.PL mice and in knock-out mice established on B10.PL background: TCRδ(-/-) mice lacking TCRγδ T lymphocytes; β2m(-/-) mice lacking CD8(+) T lymphocytes and CD1d(-/-) mice lacking CD1d dependent natural killer T (NKT) lymphocytes. B10.PL, TCRδ(-/-), β2m(-/-) and CD1d(-/-) mice were divided into six groups: 1) vehicle-treated negative control group; 2) desipramine-treated negative control group; 3) fluoxetine-treated negative control group; 4) vehicle and PCL-treated group (positive control group); 5) desipramine and PCL-treated group; and 6) fluoxetine and PCL-treated group. CHS to PCL was tested by evaluation of ear swelling. Metabolic activity of spleen and lymph node cells were estimated by MTT test. The anti...Continue Reading

References

Mar 29, 2002·Contact Dermatitis·Ian Kimber, Rebecca J Dearman
Jul 28, 2004·Trends in Immunology·Philip W AskenaseRegis A Campos
Jan 30, 2010·The Journal of Allergy and Clinical Immunology·Sabine RingKarsten Mahnke
Jul 21, 2012·Pharmacological Reports : PR·Marta KuberaWładysław Lasoń
Jan 9, 2014·Pharmacological Reports : PR·Katarzyna CurzytekMichael Maes

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Citations

Jul 28, 2016·Immunobiology·Katarzyna NazimekKrzysztof Bryniarski
Oct 11, 2017·Annual Review of Pharmacology and Toxicology·Madeline L PfauScott J Russo
Apr 17, 2019·Seminars in Immunopathology·Kwok Ho YipDamon J Tumes

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